NDLI: The human circadian metabolome

Content Provider	PubMed Central
Author	Dallmann, Robert Viola, Antoine U. Tarokh, Leila Christian, Cajochen Brown, Steven A.
Abstract	The circadian clock orchestrates many aspects of human physiology, and disruption of this clock has been implicated in various pathologies, ranging from cancer to metabolic syndrome and diabetes. Although there is evidence that metabolism and the circadian clockwork are intimately linked on a transcriptional level, whether these effects are directly under clock control or are mediated by the rest–activity cycle and the timing of food intake is unclear. To answer this question, we conducted an unbiased screen in human subjects of the metabolome of blood plasma and saliva at different times of day. To minimize indirect effects, subjects were kept in a 40-h constant routine of enforced posture, constant dim light, hourly isocaloric meals, and sleep deprivation. Under these conditions, we found that ∼15% of all identified metabolites in plasma and saliva were under circadian control, most notably fatty acids in plasma and amino acids in saliva. Our data suggest that there is a strong direct effect of the endogenous circadian clock on multiple human metabolic pathways that is independent of sleep or feeding. In addition, they identify multiple potential small-molecule biomarkers of human circadian phase and sleep pressure.
Related Links	http://dx.doi.org/10.1073/pnas.1114410109
Ending Page	2629
Page Count	5
Starting Page	2625
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-02-14
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The human circadian metabolome.

Coordination of the transcriptome and metabolome by the circadian clock

Mistimed sleep disrupts circadian regulation of the human transcriptome

Circadian Clocks in Human Red Blood Cells

Circadian Variation of the Human Metabolome Captured by Real-Time Breath Analysis

Coordination of the transcriptome and metabolome by the circadian clock.

Entrainment of the human circadian pacemaker to longer-than-24-h days

Noninvasive method for assessing the human circadian clock using hair follicle cells

Jumonji domain protein JMJD5 functions in both the plant and human circadian systems

The human circadian metabolome

Similar Documents

The human circadian metabolome.

Coordination of the transcriptome and metabolome by the circadian clock

Mistimed sleep disrupts circadian regulation of the human transcriptome

Circadian Clocks in Human Red Blood Cells

Circadian Variation of the Human Metabolome Captured by Real-Time Breath Analysis

Coordination of the transcriptome and metabolome by the circadian clock.

Entrainment of the human circadian pacemaker to longer-than-24-h days

Noninvasive method for assessing the human circadian clock using hair follicle cells

Jumonji domain protein JMJD5 functions in both the plant and human circadian systems

The human circadian metabolome