NDLI: Monoclonal Antibodies for the Treatment of Cancer

Content Provider	PubMed Central
Author	Shuptrine, Casey Surana, Rishi Weiner, Louis M.
Copyright Year	2011
Abstract	Over the past decade, the clinical utility of monoclonal antibodies has been realized and antibodies are now a mainstay for the treatment of cancer. Antibodies have the unique capacity to target and kill tumor cells while simultaneously activating immune effectors to kill tumor cells through the complement cascade or antibody-dependent cellular cytotoxicity (ADCC). This multifaceted mechanism of action combined with target specificity underlies the capacity of antibodies to elicit anti-tumor responses while minimizing the frequency and magnitude of adverse events. This review will focus on mechanisms of action, clinical applications and putative mechanisms of resistance to monoclonal antibody therapy in the context of cancer.
Related Links	http://dx.doi.org/10.1016/j.semcancer.2011.12.009
Ending Page	13
Page Count	11
Starting Page	3
File Format	PDF
ISSN	1044579X
e-ISSN	10963650
Journal	Seminars in Cancer Biology
Issue Number	1
Volume Number	22
Language	English
Publisher Date	2012-02-01
Access Restriction	Open
Subject Keyword	Cancer Research Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research

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Monoclonal Antibodies for the Treatment of Cancer