NDLI: The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations

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The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations

Content Provider	PubMed Central
Author	Andersson, Lisa S. Swinbune, June E. Meadows, Jennifer R. S. Hans, Broström Eriksson, Susanne Freddy, Fikse W. Frey, Rebecka Sundquist, Marie Tseng, Chia T. Mikko, Sofia Lindgren, Gabriella
Abstract	Insect bite hypersensitivity (IBH) is a chronic allergic dermatitis common in horses. Affected horses mainly react against antigens present in the saliva from the biting midges, Culicoides ssp, and occasionally black flies, Simulium ssp. Because of this insect dependency, the disease is clearly seasonal and prevalence varies between geographical locations. For two distinct horse breeds, we genotyped four microsatellite markers positioned within the MHC class II region and sequenced the highly polymorphic exons two from DRA and DRB3, respectively. Initially, 94 IBH-affected and 93 unaffected Swedish born Icelandic horses were tested for genetic association. These horses had previously been genotyped on the Illumina Equine SNP50 BeadChip, which made it possible to ensure that our study did not suffer from the effects of stratification. The second population consisted of 106 unaffected and 80 IBH-affected Exmoor ponies. We show that variants in the MHC class II region are associated with disease susceptibility (p raw = 2.34 × 10−5), with the same allele (COR112:274) associated in two separate populations. In addition, we combined microsatellite and sequencing data in order to investigate the pattern of homozygosity and show that homozygosity across the entire MHC class II region is associated with a higher risk of developing IBH (p = 0.0013). To our knowledge this is the first time in any atopic dermatitis suffering species, including man, where the same risk allele has been identified in two distinct populations.
Related Links	http://dx.doi.org/10.1007/s00251-011-0573-1
Ending Page	208
Page Count	8
Starting Page	201
File Format	PDF
ISSN	00937711
e-ISSN	14321211
Journal	Immunogenetics
Issue Number	3
Volume Number	64
Language	English
Publisher	Springer-Verlag
Publisher Date	2012-03-01
Access Restriction	Open
Rights Holder	Springer-Verlag
Subject Keyword	Immunology Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Immunology

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The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations

Erratum to: The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations

Erratum to: The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations

The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations

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Distinct populations of class II molecules identified by monoclonal antibodies.

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The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations

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The same ELA class II risk factors confer equine insect bite hypersensitivity in two distinct populations

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