NDLI: Estrogen receptor-α expression in neuronal cells affects bone mass

Content Provider	PubMed Central
Author	Ohlsson, Claes Engdahl, Cecilia Börjesson, Anna E. Windahl, Sara H. Studer, Erik Westberg, Lars Eriksson, Elias Koskela, Antti Tuukkanen, Juha Andree, Krust Chambon, Pierre Carlsten, Hans Lagerquist, Marie K.
Abstract	It has generally been assumed that bone mass is controlled by endocrine mechanisms and the local bone environment. Recent findings demonstrate that central pathways are involved in the regulation of bone mass. Estrogen is involved in the regulation of bone homeostasis and the CNS is also a target for estrogen actions. The aim of this study was to investigate in vivo the role of central estrogen receptor-α (ERα) expression for bone mass. Nestin-Cre mice were crossed with ERαflox mice to generate mice lacking ERα expression specifically in nervous tissue (nestin-ERα−/−). Bone mineral density was increased in both the trabecular and cortical bone compartments in nestin-ERα−/− mice compared with controls. Femoral bone strength was increased in nestin-ERα−/− mice, as demonstrated by increased stiffness and maximal load of failure. The high bone mass phenotype in nestin-ERα−/− mice was mainly caused by increased bone formation. Serum leptin levels were elevated as a result of increased leptin expression in white adipose tissue (WAT) and slightly increased amount of WAT in nestin-ERα−/− mice. Leptin receptor mRNA levels were reduced in the hypothalamus but not in bone. In conclusion, inactivation of central ERα signaling results in increased bone mass, demonstrating that the balance between peripheral stimulatory and central inhibitory ERα actions is important for the regulation of bone mass. We propose that the increased bone mass in nestin-ERα−/− mice is mediated via decreased central leptin sensitivity and thereby increased secretion of leptin from WAT, which, in turn, results in increased peripheral leptin-induced bone formation.
Related Links	http://dx.doi.org/10.1073/pnas.1111436109
Ending Page	988
Page Count	6
Starting Page	983
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	109
Language	English
Publisher	National Academy of Sciences
Publisher Date	2012-01-17
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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