Loading...
Please wait, while we are loading the content...
Similar Documents
Morphine potentiates neuropathogenesis of SIV infection in rhesus macaques
| Content Provider | PubMed Central |
|---|---|
| Author | Bokhari, Sirosh M. Hegde, Ramakrishna Callen, Shannon Yao, Honghong Istvan, Adany Li, Qingsheng Li, Zhuang Pinson, David Yeh, Hung-wen Cheney, Paul D. Buch, Shilpa |
| Abstract | Despite the advent of antiretroviral therapy, complications of HIV-1 infection with concurrent drug abuse are an emerging problem. Opiates are well-known to modulate immune responses by preventing the development of cell-mediated immune responses. Their effect on the pathogenesis of HIV-1 infection however, remains controversial. Using the Simian Immunodeficiency Virus/macaque model of HIV pathogenesis, we sought to explore the impact of morphine on disease progression and pathogenesis. Sixteen Rhesus macaques were divided into 2 groups; 4 were administered saline and twelve others morphine routinely. Both groups of animals were then inoculated with SIVmacR71/17E and followed longitudinally for disease pathogenesis. The morphine group (M+V) exhibited a trend towards higher mortality rates and retardation in weight gain compared to the virus alone group. Interestingly, a subset of M+V animals succumbed to disease within weeks post-infection. These rapid progressors also exhibited a higher incidence of other end-organ pathologies. Despite the higher numbers of circulating CD4+ and CD8+T cells in the M+V group, CD4:CD8 ratios between the groups remained unchanged. Plasma and CSF viral load in the M+V group was at least a log higher than the control group. Similarly there was a trend toward increased virus build-up in the brains of M+V animals compared with controls. A novel finding of this study was the increased influx of infected monocyte/macrophages in the brains of M+V animals. |
| Related Links | http://dx.doi.org/10.1007/s11481-011-9272-9 |
| Ending Page | 639 |
| Page Count | 14 |
| Starting Page | 626 |
| File Format | |
| ISSN | 15571890 |
| e-ISSN | 15571904 |
| Journal | Journal of Neuroimmune Pharmacology |
| Issue Number | 4 |
| Volume Number | 6 |
| Language | English |
| Publisher Date | 2011-12-01 |
| Access Restriction | Open |
| Subject Keyword | Immunology Immunology and Allergy Pharmacology Neuroscience (miscellaneous) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Immunology and Allergy Pharmacology Immunology |
