NDLI: Identifying Quantitative Trait Loci Affecting Resistance to Congenital Hypothyroidism in 129 +Ter /SvJcl Strain Mice

Content Provider	PubMed Central
Author	Hosoda, Yayoi Sasaki, Nobuya Kameda, Yayoi Torigoe, Daisuke Agui, Takashi
Editor	Zwick, Michael Edward
Copyright Year	2012
Abstract	Tyrosylprotein sulfotransferase 2 (TPST2) is one of the enzymes responsible for tyrosine O-sulfation and catalyzes the sulfation of the specific tyrosine residue of thyroid stimulating hormone receptor (TSHR). Since this modification is indispensable for the activation of TSH signaling, a non-functional TPST2 mutation (Tpst2grt ) in DW/J-grt mice leads to congenital hypothyroidism (CH) characterized by severe thyroid hypoplasia and dwarfism related to TSH hyporesponsiveness. Previous studies indicated that the genetic background of the 129 +Ter /SvJcl (129) mouse strain ameliorates Tpst2grt -induced CH. To identify loci responsible for CH resistance in 129 mice, we performed quantitative trait locus (QTL) analysis using backcross progenies from susceptible DW/J and resistant 129 mice. We used the first principal component calculated from body weights at 5, 8 and 10 weeks as an indicator of CH, and QTL analysis mapped a major QTL showing a highly significant linkage to the distal portion of chromosome (Chr) 2; between D2Mit62 and D2Mit304, particularly close to D2Mit255. In addition, two male-specific QTLs showing statistically suggestive linkage were also detected on Chrs 4 and 18, respectively. All QTL alleles derived from the 129 strain increased resistance to growth retardation. There was also a positive correlation between recovery from thyroid hypoplasia and the presence of the 129 allele at D2Mit255 in male progenies. These results suggested that the major QTL on Chr 2 is involved in thyroid development. Moreover, since DW/J congenic strain mice carrying both a Tpst2grt mutation and 129 alleles in the major QTL show resistance to dwarfism and thyroid hypoplasia, we confirmed the presence of the resistant gene in this region, and that it is involved in thyroid development. Further genetical analysis should lead to identification of genes for CH tolerance and, from a better understanding of thyroid organogenesis and function, the subsequent development of new treatments for thyroid disorders.
Related Links	http://dx.doi.org/10.1371/journal.pone.0031035
Starting Page	31035
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	1
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-01-27
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Quantitative Trait Loci for Resistance to the Congenital Nephropathy in Tensin 2-Deficient Mice

Quantitative trait loci affecting starvation resistance in Drosophila melanogaster.

Identifying Quantitative Trait Loci and Candidate Genes Conferring Resistance to Soybean Mosaic Virus SC7 by Quantitative Trait Loci-Sequencing in Soybean

Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster

Identification of quantitative trait loci affecting body composition in a mouse intercross

Quantitative Trait Loci Affecting Liver Fat Content in Mice

Congenital Sensorineural Deafness in Dalmatian Dogs Associated with Quantitative Trait Loci

Identification of quantitative trait loci affecting body composition in a mouse intercross

Morphologic analysis of spontaneous teratocarcinogenesis in developing testes of strain 129/Sv-ter mice.

Identifying Quantitative Trait Loci Affecting Resistance to Congenital Hypothyroidism in 129 +Ter /SvJcl Strain Mice

Similar Documents

Quantitative Trait Loci for Resistance to the Congenital Nephropathy in Tensin 2-Deficient Mice

Quantitative trait loci affecting starvation resistance in Drosophila melanogaster.

Identifying Quantitative Trait Loci and Candidate Genes Conferring Resistance to Soybean Mosaic Virus SC7 by Quantitative Trait Loci-Sequencing in Soybean

Sex-specific quantitative trait loci affecting longevity in Drosophila melanogaster

Identification of quantitative trait loci affecting body composition in a mouse intercross

Quantitative Trait Loci Affecting Liver Fat Content in Mice

Congenital Sensorineural Deafness in Dalmatian Dogs Associated with Quantitative Trait Loci

Identification of quantitative trait loci affecting body composition in a mouse intercross

Morphologic analysis of spontaneous teratocarcinogenesis in developing testes of strain 129/Sv-ter mice.

Identifying Quantitative Trait Loci Affecting Resistance to Congenital Hypothyroidism in 129 +Ter /SvJcl Strain Mice