NDLI: Penicillamine Neurotoxicity: An Hypothesis

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Penicillamine Neurotoxicity: An Hypothesis

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Penicillamine Neurotoxicity: An Hypothesis

Content Provider	PubMed Central
Author	Walshe, J. M.
Copyright Year	2011
Abstract	Penicillamine, dimethyl cysteine, thiovaline, remains the drug of choice for the treatment of patience with Wilson disease. It is also of value in the treatment of cysteinuria and rheumatoidarthritis, it has also been suggested that it has value in the management of other rare diseases. It also has multiple toxicities. The majority of these can be explained as chemical toxicity, for instance its weak antipyridoxine action and its ability to interfere with lysyloxidea resulting in skin lesions. More important are its ability to induce immune reactions such as SLE, immune complex nephritis, the Ehlers Danlos syndrome and Goodpasture's syndrome. However the sudden increase in neurological signs which may occur in a small number of patients remains unexplained. The theory is proposed that this is due tolethal synthesis. In susceptible patients the–SH radical is liberated from penicillamine and will inhibit–SH dependent enzymes in the Krebs cycle leading to death in neurones. Othertoxic metabolites may also be produced such as methyl mercaptan and ethyl mercaptan either of which could produce a similar metabolic block.
Related Links	http://dx.doi.org/10.5402/2011/464572
Starting Page	464572
File Format	PDF
ISSN	20905513
e-ISSN	20905513
Journal	ISRN Neurology
Volume Number	2011
Language	English
Publisher	International Scholarly Research Network
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	International Scholarly Research Network
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article

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