NDLI: Planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair

Content Provider	PubMed Central
Author	Dworkin, Sebastian Jane, Stephen M. Charbel, Darido
Copyright Year	2011
Abstract	The planar cell polarity (PCP) pathway plays a critical role in diverse developmental processes that require coordinated cellular movement, including neural tube closure and renal tubulogenesis. Recent studies have demonstrated that this pathway also has emerging relevance to the epidermis, as PCP signaling underpins many aspects of skin biology and pathology, including epidermal development, hair orientation, stem cell division and cancer. Coordinated cellular movement required for epidermal repair in mammals is also regulated by PCP signaling, and in this context, a new PCP gene encoding the developmental transcription factor Grainyhead-like 3 (Grhl3) is critical. This review focuses on the role that PCP signaling plays in the skin across a variety of epidermal functions and highlights perturbations that induce epidermal pathologies.
Related Links	http://dx.doi.org/10.4161/org.7.3.18431
Ending Page	208
Page Count	7
Starting Page	202
File Format	PDF
ISSN	15476278
e-ISSN	15558592
Journal	Organogenesis
Issue Number	3
Volume Number	7
Language	English
Publisher	Landes Bioscience
Publisher Date	2011-07-01
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Developmental Biology Embryology Transplantation Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Transplantation Embryology Biomedical Engineering

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Planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair