NDLI: B cell Depletion Enhances T Regulatory Cell Activity Essential in the Suppression of Arthritis

Content Provider	PubMed Central
Author	Hamel, Keith Cao, Yanxia Susan, Ashaye Wang, Yumei Dunn, Robert Kehry, Marilyn R. Glant, Tibor T. Finnegan, Alison
Abstract	The efficacy of B cell depletion therapy in rheumatoid arthritis (RA) has driven interest in understanding the mechanism. Because the decrease in autoantibododies in RA does not necessarily correlate with clinical outcome other mechanisms may be operative. We previously reported in proteoglycan-induced arthritis (PGIA), B cell depletion inhibits autoreactive T cell responses. Recent studies in B cell depletion therapy also indicate a role for B cells in suppressing regulatory mechanisms. Here we demonstrate that B cells inhibited both the expansion and the function of T regulatory (Treg) cells in PGIA. Utilizing an anti-CD20 mAb, we depleted B cells from mice with PGIA and assessed the Treg cell population. Compared to control antibody-treated mice, Treg cell percentages were elevated in B cell-depleted mice, with a higher proportion of CD4+ T cells expressing Foxp3 and CD25. On a per cell basis, CD4+CD25+ cells from B cell depleted mice expressed increased amounts of Foxp3 and were significantly more suppressive than those from control Ab-treated mice. The depletion of Treg cells with an anti-CD25 mAb concurrent with B cell depletion therapy restored the severity of PGIA to levels equal to untreated mice. Although titers of autoantibodies did not recover to untreated levels, CD4+ T cell recall responses to the immunizing antigen returned as measured by T cell proliferation and cytokine production. Thus, B cells have the capacity to regulate inflammatory responses by enhancing T effector cells along with suppressing Treg cells.
Related Links	http://dx.doi.org/10.4049/jimmunol.1101844
Ending Page	4906
Page Count	7
Starting Page	4900
File Format	PDF
ISSN	00221767
e-ISSN	15506606
Journal	Journal of immunology (Baltimore, Md. : 1950)
Issue Number	9
Volume Number	187
Language	English
Publisher Date	2011-11-01
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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