NDLI: Notch-dependent induction of left/right asymmetry in C. elegans interneurons and motoneurons

Content Provider	PubMed Central
Author	Bertrand, Vincent Bisso, Paul Poole, Richard J. Hobert, Oliver
Copyright Year	2011
Abstract	Although invertebrate and vertebrate nervous systems are largely bilateral symmetric on a structural level, they display striking degrees of functional left/right (L/R) asymmetry. In Caenorhabditis elegans two structurally symmetric pairs of sensory neurons, ASE and AWC display distinct types of functional L/R asymmetry (stereotyped vs. stochastic asymmetry), which are controlled by distinct molecular mechanisms [1–3]. Beyond these two cases, the extent of neuronal asymmetry in the C. elegans nervous system and the types and diversities of mechanisms that control other potential asymmetries remain to be determined. Here, we report that the Beta3/Olig-type bHLH transcription factor hlh-16 is L/R asymmetrically expressed in several distinct, otherwise bilaterally symmetric interneuron and motoneuron pairs. These neuron pairs are part of a known circuit controlling C. elegans navigation. We find that hlh-16 asymmetry is generated during gastrulation by an asymmetric LAG-2/Delta signal originating from the mesoderm. This signal promotes hlh-16 expression in neurons on the left side through direct binding of the Notch effector LAG-1/Su(H)/CBF to a cis-regulatory element in the hlh-16 locus. Through the removal of hlh-16 we reveal an unanticipated asymmetry in the ability of the axons of the AIY interneurons to extend into the nerve ring, with the left AIY axon requiring elevated hlh-16 expression for correct extension. Taken together, our study suggests that the extent of molecular L/R asymmetry in the C. elegans nervous system is broader than previously anticipated, it establishes a novel signaling mechanism that crosses germ layers to diversify bilaterally symmetric neuronal lineages, and reveals L/R asymmetric control of axonal outgrowth of bilaterally symmetric neurons.
Related Links	http://dx.doi.org/10.1016/j.cub.2011.06.016
Ending Page	1231
Page Count	7
Starting Page	1225
File Format	PDF
ISSN	09609822
e-ISSN	18790445
Journal	Current biology : CB
Issue Number	14
Volume Number	21
Language	English
Publisher Date	2011-07-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Biochemistry, Genetics and Molecular Biology Agricultural and Biological Sciences

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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