NDLI: DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

Please wait, while we are loading the content...

Year: 2016, Volume: 113

Year: 2015, Volume: 112

Year: 2014, Volume: 111

Year: 2013, Volume: 110

Year: 2012, Volume: 109

Year: 2011, Volume: 109

Year: 2011, Volume: 108

Year: 2010, Volume: 107

Year: 2009, Volume: 106

Year: 2009, Volume: 94

Year: 2008, Volume: 105

Year: 2007, Volume: 104

Year: 2006, Volume: 103

Year: 2005, Volume: 103

Year: 2005, Volume: 102

Year: 2004, Volume: 101

Year: 2003, Volume: 100

Year: 2002, Volume: 99

Year: 2001, Volume: 98

Year: 2000, Volume: 97

Year: 1999, Volume: 96

Year: 1998, Volume: 95

Year: 1997, Volume: 94

Year: 1996, Volume: 93

Year: 1995, Volume: 92

Year: 1994, Volume: 91

Year: 1993, Volume: 90

Year: 1992, Volume: 89

Year: 1991, Volume: 88

Year: 1990, Volume: 87

Year: 1989, Volume: 86

Year: 1988, Volume: 85

Year: 1987, Volume: 84

Year: 1986, Volume: 83

Year: 1986, Volume: 83, Issue: Suppl

Year: 1986, Volume: 83, Issue: 24

Year: 1986, Volume: 83, Issue: 23

Year: 1986, Volume: 83, Issue: 22

Year: 1986, Volume: 83, Issue: 21

Year: 1986, Volume: 83, Issue: 20

Year: 1986, Volume: 83, Issue: 19

Year: 1986, Volume: 83, Issue: 18

Year: 1986, Volume: 83, Issue: 17

Year: 1986, Volume: 83, Issue: 16

Year: 1986, Volume: 83, Issue: 15

Year: 1986, Volume: 83, Issue: 14

Year: 1986, Volume: 83, Issue: 13

Year: 1986, Volume: 83, Issue: 12

Year: 1986, Volume: 83, Issue: 11

Year: 1986, Volume: 83, Issue: 10

Year: 1986, Volume: 83, Issue: 9

Year: 1986, Volume: 83, Issue: 8

Year: 1986, Volume: 83, Issue: 7

Year: 1986, Volume: 83, Issue: 6

The nil Hecke ring and cohomology of G/P for a Kac-Moody group G

An optimal property of the repeated significance test

Benzyl acetates as attractants for the male oriental fruit fly, Dacus dorsalis, and the male melon fly, Dacus cucurbitae

Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity.

Identification of the polypeptides encoded in the unassigned reading frames 2, 4, 4L, and 5 of human mitochondrial DNA.

Large introns in the 3' end of the gene for the pro alpha 1 (IV) chain of human basement membrane collagen.

Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library.

Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen.

Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase.

Site-saturation studies of beta-lactamase: production and characterization of mutant beta-lactamases with all possible amino acid substitutions at residue 71.

Identification of the binding site on 5S rRNA for the transcription factor IIIA: proposed structure of a common binding site on 5S rRNA and on the gene.

Trans effect of the E1 region of adenoviruses on the expression of a prokaryotic gene in mammalian cells: resistance to 5' -CCGG- 3' methylation.

Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.

On the specificity of DNA-protein interactions.

Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase.

B- to Z-DNA transition probed by oligonucleotides containing methylphosphonates.

Yeast and mammals utilize similar cytosolic components to drive protein transport through the Golgi complex.

Hepatitis B virus DNA contains a glucocorticoid-responsive element.

Short-circuiting the visual cycle with retinotoxic aromatic amines.

In vitro synthesis of the iron-molybdenum cofactor of nitrogenase.

DNA supercoiling of recombinant plasmids in mammalian cells.

DNA binding site for a factor(s) required to initiate simian virus 40 DNA replication.

Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line.

AMP-insensitive fructose bisphosphatase in Escherichia coli and its consequences.

Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site.

Isolation and characterization of human glycophorin A cDNA clones by a synthetic oligonucleotide approach: nucleotide sequence and mRNA structure.

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

Expression of a cDNA derived from the yeast killer preprotoxin gene: implications for processing and immunity.

ATP inhibits nuclear and mitochondrial type I topoisomerases from human leukemia cells.

Cytolytic effects of neutrophils: role for a membrane-bound neutral proteinase.

Primary electron transfer reactions in modified reaction centers from Rhodopseudomonas sphaeroides

Spin glass model of learning by selection.

Excitation trapping and primary charge stabilization in Rhodopseudomonas viridis cells, measured electrically with picosecond resolution

Mechanism by which contact with plant cuticle triggers cutinase gene expression in the spores of Fusarium solani f. sp. pisi

Bovine parathyroid cells: cultures maintained for more than 140 population doublings.

Identification and preferential expression in thymic and bursal lymphocytes of a c-ets oncogene-encoded Mr 54,000 cytoplasmic protein.

Visualization of the Ca2+-transport system of the mitotic apparatus of sea urchin eggs with a monoclonal antibody

Fetal characteristics of small intestinal crypt cells.

ATP-dependent formation and motility of aster-like structures with isolated calf brain microtubule proteins.

Stimulation of ribosomal protein S6 kinase activity by pp60v-src or by serum: dissociation from phorbol ester-stimulated activity.

DNA amplification and neoplastic transformation mediated by a herpes simplex DNA fragment containing cell-related sequences.

Norepinephrine-induced alteration in the coupling of alpha 1-adrenergic receptor occupancy to calcium efflux in rabbit aortic smooth muscle cells.

Transcription regulation of peroxisomal fatty acyl-CoA oxidase and enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase in rat liver by peroxisome proliferators.

Oligosaccharide modification by swainsonine treatment inhibits pulmonary colonization by B16-F10 murine melanoma cells.

Conservation of extended promoter regions of nodulation genes in Rhizobium

Double-strand gap repair results in homologous recombination in mouse L cells.

DNA modification of a maize transposable element correlates with loss of activity.

Nucleotide sequence of the human N-myc gene.

A chimeric plasmid from cDNA clones of poliovirus and coxsackievirus produces a recombinant virus that is temperature-sensitive.

Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene.

Quantitation of insertion sequence IS10 transposase gene expression by a method generally applicable to any rarely expressed gene.

Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans.

Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activity.

Information transfer between duplicated chromosomal sequences in mammalian cells involves contiguous regions of DNA.

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

Heat shock locus 93D of Drosophila melanogaster: a spliced RNA most strongly conserved in the intron sequence.

Sialidosis and galactosialidosis: chromosomal assignment of two genes associated with neuraminidase-deficiency disorders.

Assignment of the gene for the beta subunit of thyroid-stimulating hormone to the short arm of human chromosome 1.

Structure and expression of the murine N-myc gene.

cDNA cloning of the complete genome of tobacco mosaic virus and production of infectious transcripts

Bacterial δ-aminolevulinic acid synthase activity is not essential for leghemoglobin formation in the soybean/Bradyrhizobium japonicum symbiosis

A yeast excision-repair gene is inducible by DNA damaging agents.

Somatic evolution of variable region structures during an immune response.

Glycosylation of the T-cell antigen-specific receptor and its potential role in lectin-mediated cytotoxicity.

Characterization of a murine lymphokine distinct from interleukin 2 and interleukin 3 (IL-3) possessing a T-cell growth factor activity and a mast-cell growth factor activity that synergizes with IL-3.

Early precursor thymocytes can produce interleukin 2 upon stimulation with calcium ionophore and phorbol ester.

Rearrangements of DNA mediated by terminal transferase.

Antibodies to synthetic joining segment peptide of the T-cell receptor beta-chain: serological cross-reaction between products of T-cell receptor genes, antigen binding T-cell receptors, and immunoglobulins.

Early transmembrane events in alloimmune cytotoxic T-lymphocyte activation as revealed by stopped-flow fluorometry.

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

Autocrine growth inhibition of a cloned line of helper T cells.

Gene products specifying adhesion of uropathogenic Escherichia coli are minor components of pili.

Synthesis and biological activity of highly potent octapeptide analogs of somatostatin.

Sodium-23 magnetic resonance imaging of the eye and lens.

Resistance to human respiratory syncytial virus (RSV) infection induced by immunization of cotton rats with a recombinant vaccinia virus expressing the RSV G glycoprotein.

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

Bile acids regulate hepatic low density lipoprotein receptor activity in the hamster by altering cholesterol flux across the liver.

Distribution of corticotropin-releasing factor receptors in primate brain.

Expression of Mycobacterium leprae genes from a Streptococcus mutans promoter in Escherichia coli K-12.

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

Isolation and structure of a C-terminally amidated nonopioid peptide, amidorphin-(8-26), from bovine striatum: a major product of proenkephalin in brain but not in adrenal medulla.

Fast and slow synaptic potentials produced in a mammalian sympathetic ganglion by colon distension.

Voltage-gated and synaptic currents in rat Purkinje cells in dissociated cell cultures.

Nerve growth factor receptor molecules in rat brain.

Growth requirements in vitro of oligodendrocyte cell lines and neonatal rat brain oligodendrocytes.

Proenkephalin mRNA in rat heart.

Association of 16S and 23S ribosomal RNAs to form a bimolecular complex

Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene

Year: 1986, Volume: 83, Issue: 5

Year: 1986, Volume: 83, Issue: 4

Year: 1986, Volume: 83, Issue: 3

Year: 1986, Volume: 83, Issue: 2

Year: 1986, Volume: 83, Issue: 1

Year: 1985, Volume: 82

Year: 1984, Volume: 81

Year: 1983, Volume: 80

Year: 1982, Volume: 79

Year: 1981, Volume: 78

Year: 1980, Volume: 77

Year: 1979, Volume: 76

Year: 1978, Volume: 75

Year: 1977, Volume: 74

Year: 1976, Volume: 73

Year: 1975, Volume: 72

Year: 1974, Volume: 71

Year: 1973, Volume: 70

Year: 1972, Volume: 69

Year: 1971, Volume: 68

Year: 1970, Volume: 67

Year: 1970, Volume: 66

Year: 1970, Volume: 65

Year: 1969, Volume: 64

Year: 1969, Volume: 63

Year: 1969, Volume: 62

Year: 1968, Volume: 61

Year: 1968, Volume: 60

Year: 1968, Volume: 59

Year: 1967, Volume: 58

Year: 1967, Volume: 57

Year: 1966, Volume: 56

Year: 1966, Volume: 55

Year: 1965, Volume: 54

Year: 1965, Volume: 53

Year: 1964, Volume: 52

Year: 1964, Volume: 51

Year: 1963, Volume: 50

Year: 1963, Volume: 49

Year: 1962, Volume: 48

Year: 1961, Volume: 47

Year: 1960, Volume: 46

Year: 1959, Volume: 45

Year: 1958, Volume: 44

Year: 1957, Volume: 43

Year: 1956, Volume: 42

Year: 1955, Volume: 41

Year: 1954, Volume: 40

Year: 1953, Volume: 39

Year: 1952, Volume: 38

Year: 1951, Volume: 37

Year: 1950, Volume: 36

Year: 1949, Volume: 35

Year: 1948, Volume: 34

Year: 1947, Volume: 33

Year: 1946, Volume: 32

Year: 1945, Volume: 31

Year: 1944, Volume: 30

Year: 1943, Volume: 29

Year: 1942, Volume: 28

Year: 1941, Volume: 27

Year: 1940, Volume: 26

Year: 1939, Volume: 25

Year: 1938, Volume: 24

Year: 1937, Volume: 23

Year: 1936, Volume: 22

Year: 1935, Volume: 21

Year: 1934, Volume: 20

Year: 1933, Volume: 19

Year: 1932, Volume: 18

Year: 1931, Volume: 17

Year: 1930, Volume: 16

Year: 1929, Volume: 15

Year: 1928, Volume: 14

Year: 1927, Volume: 13

Year: 1926, Volume: 12

Year: 1925, Volume: 11

Year: 1924, Volume: 10

Year: 1923, Volume: 9

Year: 1922, Volume: 8

Year: 1921, Volume: 7

Year: 1920, Volume: 6

Year: 1919, Volume: 5

Year: 1918, Volume: 4

Year: 1917, Volume: 3

Year: 1916, Volume: 2

Year: 1915, Volume: 1

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

Content Provider	PubMed Central
Author	Schmid, D. S. Tite, J. P. Ruddle, N. H.
Abstract	A Lyt-2+, trinitrophenyl-specific, lymphotoxin-secreting, cytotoxic T-cell line, PCl 55, mediates the digestion of target cell DNA into discretely sized fragments. This phenomenon manifests itself within 30 min after effector cell encounter as measured by the release of 3H counts from target cells prelabeled with [3H]deoxythymidine and occurs even at very low effector to target cell ratios (0.25:1). A Lyt-1+, ovalbumin-specific, lymphotoxin-secreting T-helper cell clone, 5.9.24, is also able to mediate fragmentation of target cell DNA over a time course essentially indistinguishable from the cytotoxic T lymphocyte-mediated hit. Cell-free lymphotoxin-containing supernatants also cause release of DNA from targets, although they require a longer time course, on the order of 24 hr. In contrast, lysis of cells by antibody plus complement or Triton X-100 does not result in DNA release even after extended periods of incubation (24 hr). All three treatments that result in the release of DNA from cells cause fragmentation of that DNA into discretely sized pieces that are multiples of 200 base pairs. The results thus suggest that cytotoxic T cells, lymphotoxin-secreting helper clones with cytolytic activity, and lymphotoxin all effect target cell destruction by means of a similar mechanism and that observed differences in time course and the absence of target cell specificity in killing mediated by lymphotoxin may simply reflect differences in the mode of toxin delivery.
Starting Page	1881
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	83
Language	English
Publisher Date	1986-03-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in