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Aging and the control of human skin blood flow
| Content Provider | PubMed Central |
|---|---|
| Author | Holowatz, Lacy A. Thompson-torgerson, Caitlin Kenney, W. Larry |
| Abstract | Human exposure to cold and heat stimulates cutaneous vasoconstriction and vasodilation via distinct sympathetic reflex and locally mediated pathways. The mechanisms mediating cutaneous vasoconstriction and vasodilation are impaired with primary aging, rendering the aged more vulnerable to hypothermia and cardiovascular complications from heat-related illness, respectively. This paper highlights recent findings discussing how age-related decrements in sympathetic neurotransmission contribute directly to thermoregulatory impairments, whereas changes in local intracellular signaling suggest a more generalized age-associated vascular dysfunction. |
| Starting Page | 718 |
| File Format | |
| ISSN | 10939946 |
| Journal | Frontiers in bioscience : a journal and virtual library |
| Volume Number | 15 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Microbiology Medicine Biochemistry, Genetics and Molecular Biology |