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| Content Provider | PubMed Central |
|---|---|
| Author | Caldorera-moore, Mary E. Liechty, William B. Peppas, Nicholas A. |
| Abstract | The ability to non-invasively monitor and treat physiological conditions within the human body has been an aspiration of researchers and medical professionals for decades. The emergences of nanotechnology opened up new possibilities for effective vehicles that could accomplish non-invasive detection of diseases and localized treatment systems to be developed. In turn, extensive research efforts have been spent on the development of imaging moiety that could be used to seek out specific diseased conditions and can be monitored with convention clinical imaging modalities. Nanoscale detection agents like these have the potential to increase early detection of pathophysiological conditions because they have the capability to detect abnormal cells before they even develop into diseased tissue and/or tumors. Once the diseased cells are detected it would be constructive to just be able to treat them simultaneously. From here, the concept of multifunctional carriers that could target, detect, and treat diseased cells emerged. The term “theranostics” has been created to describe this promising area of research that focuses on the combination of diagnostic detection agents with therapeutic drug delivery carriers. Targeted theranostic nanocarriers offer an attractive improvement to disease treatment because of their ability to simultaneously diagnose, image, and treat at targeted diseased sites. Research efforts in the field of theranostics encompass a broad variety of drug delivery vehicles, detection agents, and targeting modalities for the development of an all-in-one, localized, diagnostic and treatment system. Nanotheranostic systems that utilize metallic or magnetic imaging nanoparticles have the added capability to be used as thermal therapeutic systems. This review aims to explore recent advancements in the field of nanotheranostics and the various fundamental components of an effective theranostic carrier. |
| Related Links | http://dx.doi.org/10.1021/ar2001777 |
| Ending Page | 1070 |
| Page Count | 10 |
| Starting Page | 1061 |
| File Format | |
| ISSN | 00014842 |
| e-ISSN | 15204898 |
| Journal | Accounts of chemical research |
| Issue Number | 10 |
| Volume Number | 44 |
| Language | English |
| Publisher Date | 2011-10-18 |
| Access Restriction | Open |
| Subject Keyword | Chemistry(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Medicine |
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