NDLI: An Emerging Role for IQGAP1 in Regulating Protein Traffic

Please wait, while we are loading the content...

An Emerging Role for IQGAP1 in Regulating Protein Traffic

Content Provider	PubMed Central
Author	Osman, Mahasin A.
Copyright Year	2010
Abstract	IQGAP1, an effector of CDC42p GTPase, is a widely conserved, multifunctional protein that bundles F-actin through its N-terminus and binds microtubules through its C-terminus to modulate the cell architecture. It has emerged as a potential oncogene associated with diverse human cancers. Therefore, IQGAP1 has been heavily investigated; regardless, its precise cellular function remains unclear. Work from yeast suggests that IQGAP1 plays an important role in directed cell growth, which is a conserved feature crucial to morphogenesis, division axis, and body plan determination. New evidence suggests a conserved role for IQGAP1 in protein synthesis and membrane traffic, which may help to explain the diversity of its cellular functions. Membrane traffic mediates infections by intracellular pathogens and a range of degenerative human diseases arise from dysfunctions in intracellular traffic; thus, elucidating the mechanisms of cellular traffic will be important in order to understand the basis of a wide range of inherited and acquired human diseases. Recent evidence suggests that IQGAP1 plays its role in cell growth through regulating the conserved mTOR pathway. The mTOR signaling cascade has been implicated in membrane traffic and is activated in nearly all human cancers, but clinical response to the mTOR-specific inhibitor rapamycin has been disappointing. Thus, understanding the regulators of this pathway will be crucial in order to identify predictors of rapamycin sensitivity. In this review, I discuss emerging evidence that supports a potential role of IQGAP1 in regulating membrane traffic via regulating the mTOR pathway.
Related Links	http://dx.doi.org/10.1100/tsw.2010.85
Ending Page	953
Page Count	10
Starting Page	944
File Format	PDF
ISSN	1537744X
e-ISSN	1537744X
Journal	TheScientificWorldJournal
Volume Number	10
Language	English
Publisher Date	2010-01-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Environmental Science(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology Environmental Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray

Transition Characteristic Analysis of Traffic Evolution Process for Urban Traffic Network

Ecto-protein kinases and phosphatases: an emerging field for translational medicine

Emerging Measurement Techniques for Airborne Pollutants

An Alternative Paradigm for the Role of Antimalarial Plants in Africa

An Empirical Study of Different Approaches for Protein Classification

IQGAP1 Is Involved in Post-Ischemic Neovascularization by Regulating Angiogenesis and Macrophage Infiltration

Emerging Paradigms in Genomics-Based Crop Improvement

Emerging Water Quality Problems in Developing Countries

An Emerging Role for IQGAP1 in Regulating Protein Traffic

Similar Documents

An Emerging New Paradigm in Opioid Withdrawal: A Critical Role for Glia-Neuron Signaling in the Periaqueductal Gray

Transition Characteristic Analysis of Traffic Evolution Process for Urban Traffic Network

Ecto-protein kinases and phosphatases: an emerging field for translational medicine

Emerging Measurement Techniques for Airborne Pollutants

An Alternative Paradigm for the Role of Antimalarial Plants in Africa

An Empirical Study of Different Approaches for Protein Classification

IQGAP1 Is Involved in Post-Ischemic Neovascularization by Regulating Angiogenesis and Macrophage Infiltration

Emerging Paradigms in Genomics-Based Crop Improvement

Emerging Water Quality Problems in Developing Countries

An Emerging Role for IQGAP1 in Regulating Protein Traffic