NDLI: The Efferent Medial Olivocochlear-Hair Cell Synapse

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Content Provider	PubMed Central
Author	Belén, Elgoyhen Ana Katz, Eleonora
Copyright Year	2011
Abstract	Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca2+ permeable and is coupled to a Ca2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse.
Related Links	http://dx.doi.org/10.1016/j.jphysparis.2011.06.001
Ending Page	56
Page Count	10
Starting Page	47
File Format	PDF
ISSN	09284257
e-ISSN	17697115
Journal	Journal of Physiology, Paris
Issue Number	1-2
Volume Number	106
Language	English
Publisher Date	2012-01-01
Access Restriction	Open
Subject Keyword	Physiology (medical) Neuroscience(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Physiology (medical)

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The Efferent Medial Olivocochlear-Hair Cell Synapse