NDLI: Co-expression of metalloproteinases 11 and 12 in cervical scrapes cells from cervical precursor lesions

Content Provider	PubMed Central
Author	Valdivia, Alejandra Peralta, Raúl Manuel, Matute-gonzález Cebada, Juan Manuel García Casasola, Ivonne Cristina, Jiménez-medrano Rogelio, Aguado-pérez Villegas, Vanessa Cesar, González-bonilla Leticia, Manuel-apolinar Ibáñez, Miguel Salcedo, Mauricio
Copyright Year	2011
Abstract	The metalloproteinases (MMP) 11 and 12 have been shown to be expressed in cervical cancer (CC). In order to extend our previous results, these MMPs were evaluated in cervical precursor lesions. One hundred seventeen cervical scrapes: thirty-six normal, thirty-six Low grade squamous lesions (LSIL), thirty-six High grade (HSIL), nine CC; and, also ninety-nine paraffin-embedded cervical lesions: fifteen normal cervices, thirty eight LSIL, sixteen HSIL, and five CC were collected. The samples were analyzed for relative expression by real time RT-PCR or immunohistochemistry assay. We were able to identify a relative increased expression of MMP11 in 75% and 78% from LSIL and HSIL samples, respectively. While MMP12 expression was 64% and 75% in LSIL and HSIL, respectively. Positive samples for MMP11 expression were also positive for MMP12 expression and also increased according to illness progression. In the tissues, MMP11 or MMP12 expression was observed in the cytoplasm of the neoplastic cells, while in the normal epithelium was absent. The reaction was always stronger for MMP12 than MMP11. MMP11 expression was present in 77% and 66% of LSIL and HSIL, while MMP12 expression was 73% and 68%. There was a relationship between MMP11 or MMP12 expression and HPV infection. Our data are showing a relationship between diagnostic of precursor lesions and the MMP11 and 12 expressions, suggesting that their expression could be an early event in the neoplastic lesions of the cervix and could have clinical significance.
Ending Page	682
Starting Page	674
File Format	PDF
ISSN	19362625
e-ISSN	19362625
Journal	International Journal of Clinical and Experimental Pathology
Issue Number	7
Volume Number	4
Language	English
Publisher	e-Century Publishing Corporation
Publisher Date	2011-10-12
Access Restriction	Open
Rights Holder	e-Century Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Histology Pathology and Forensic Medicine

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