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| Content Provider | PubMed Central |
|---|---|
| Author | Park, Chan Ho Rios, Hector F. Jin, Qiming Sugai, James V. Miguel, Padial-molina Taut, Andrei D. Flanagan, Colleen L. Hollister, Scott J. Giannobile, William V. |
| Copyright Year | 2011 |
| Abstract | Regeneration of bone-ligament complexes destroyed due to disease or injury is a clinical challenge due to complex topologies and tissue integration required for functional restoration. Attempts to reconstruct soft-hard tissue interfaces have met with limited clinical success. In this investigation, we manufactured biomimetic fiber-guiding scaffolds using solid free-form fabrication methods that custom fit complex anatomical defects to guide functionally-oriented ligamentous fibers in vivo. Compared to traditional, amorphous or random-porous polymeric scaffolds, the use of perpendicularly oriented microchannels provides better guidance for cellular processes anchoring ligaments between two distinct mineralized structures. These structures withstood biomechanical loading to restore large osseous defects. Cell transplantation using hybrid scaffolding constructs with guidance channels resulted in predictable oriented fiber architecture, greater control of tissue infiltration, and better organization of ligament interface than random scaffold architectures. These findings demonstrate that fiber-guiding scaffolds drive neogenesis of triphasic bone-ligament integration for a variety of clinical scenarios. |
| Related Links | http://dx.doi.org/10.1016/j.biomaterials.2011.09.057 |
| Ending Page | 145 |
| Page Count | 9 |
| Starting Page | 137 |
| File Format | |
| ISSN | 01429612 |
| e-ISSN | 18785905 |
| Journal | Biomaterials |
| Issue Number | 1 |
| Volume Number | 33 |
| Language | English |
| Publisher Date | 2012-01-01 |
| Access Restriction | Open |
| Subject Keyword | Biophysics Mechanics of Materials Bioengineering Biomaterials Ceramics and Composites Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Nanoscience and Nanotechnology Mechanics of Materials Biomaterials Biophysics Bioengineering |
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