NDLI: Non-Steroidal Anti-inflammatory Drug Use and Risk of Adenomatous and Hyperplastic Polyps

Content Provider	PubMed Central
Author	Murff, Harvey J. Shrubsole, Martha J. Chen, Zhi Smalley, Walter E. Chen, Heidi Shyr, Yu Ness, Reid M. Zheng, Wei
Abstract	Adenomatous polyps are known precursor lesions for colorectal cancer and some hyperplastic polyps also have malignant potential. The use of aspirin and non-steroidal anti-inflammatory drugs (NSAIDS) is associated with a reduced risk of adenomatous polyps; however, less evidence exists regarding NSAID use and hyperplastic polyp risk. We conducted a colonoscopy-based case-control study including 2028 polyp cases (1,529 adenomatous and 499 hyperplastic) and 3,431 polyp-free controls. Multivariate logistic regression models were constructed to derived adjusted odds ratios (OR) and 95% confidence intervals (CI) as the measure of the association between NSAID use and polyp risk. Use of baby aspirin, regular aspirin, and non-aspirin NSAIDs, were associated with a reduced risk of adenomatous polyps (OR = 0.79; 95% CI 0.66–0.93, OR = 0.73; 0.58–0.90, and OR = 0.67; 0.53–0.86, respectively). Baby aspirin was also associated with a reduced risk of hyperplastic polyps (OR = 0.74; 0.56–0.97). Although a dose response was seen with adenoma risk and regular use of any NSAIDs (less than 7 doses per week, 7 doses per week, and greater than 7 doses per week), a dose response was not seen with hyperplastic polyps. We found no evidence of interaction between NSAID dose and duration and polyp risk. The use of any NSAID regardless of type was associated with a reduced risk of adenomatous polyps however regular aspirin and COX-2 inhibitors use was not associated with hyperplastic polyp risk.
Related Links	http://dx.doi.org/10.1158/1940-6207.capr-11-0107
Ending Page	1807
Page Count	9
Starting Page	1799
File Format	PDF
ISSN	19406207
e-ISSN	19406215
Journal	Cancer prevention research (Philadelphia, Pa.)
Issue Number	11
Volume Number	4
Language	English
Publisher Date	2011-11-01
Access Restriction	Open
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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