NDLI: Genetic Variants and Susceptibility to Neurological Complications Following West Nile Virus Infection

Content Provider	PubMed Central
Author	Loeb, Mark Eskandarian, Sasha Rupp, Mark Fishman, Neil Gasink, Leanne Patterson, Jan Bramson, Jonathan Hudson, Thomas J. Lemire, Mathieu
Copyright Year	2011
Abstract	To determine genetic factors predisposing to neurological complications following West Nile virus infection, we analyzed a cohort of 560 neuroinvasive case patients and 950 control patients for 13 371 mostly nonsynonymous single-nucleotide polymorphisms (SNPs). The top 3 SNPs on the basis of statistical significance were also in genes of biological plausibility: rs2066786 in RFC1 (replication factor C1) (P = 1.88 × 10−5; odds ratio [OR], 0.68 [95% confidence interval {CI}, .56–.81]); rs2298771 in SCN1A (sodium channel, neuronal type I α subunit) (P = 5.87 × 10−5; OR, 1.47 [95% CI, 1.21–1.77]); and rs25651 in ANPEP (ananyl aminopeptidase) (P = 1.44 × 10−4; OR, 0.69 [95% CI, .56–.83]). Additional genotyping of these SNPs in a separate sample of 264 case patients and 296 control patients resulted in a lack of significance in the replication cohort; joint significance was as follows: rs2066786, P = .0022; rs2298771, P = .005; rs25651, P = .042. Using mostly nonsynonymous variants, we therefore did not identify genetic variants associated with neuroinvasive disease.
Related Links	http://dx.doi.org/10.1093/infdis/jir493
Ending Page	1037
Page Count	7
Starting Page	1031
File Format	PDF
ISSN	00221899
e-ISSN	15376613
Journal	The Journal of Infectious Diseases
Issue Number	7
Volume Number	204
Language	English
Publisher	Oxford University Press
Publisher Date	2011-10-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Immunology and Allergy Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Immunology and Allergy

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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