NDLI: In Silico Analyses of Mouse Inner-Ear Transcripts

Content Provider	PubMed Central
Author	Klockars, Tuomas Perheentupa, Teemu Dahl, Hans-henrik M.
Abstract	The development and function of the inner ear is complex requiring the correct and coordinated expression of many genes. The recent progress in the analyses of the human and other genomes has provided tools for identification of genes involved in hearing. As more and more nucleotide sequence information accumulates, experimental methods of molecular biology are rapidly being supplemented, and partially supplanted, by computational methods. In this study we present comprehensive in silico analyses of a cDNA library representing almost 1600 transcripts isolated from mouse inner ear. By mining the public databases we were able to rapidly and efficiently identify numerous transcripts likely to have a specific role in the auditory or vestibular function of the inner ear. Analyses revealed about 600 known genes and almost 100 inner-ear specific transcripts. Almost 50 of these are candidate genes for hearing impairment based on their chromosomal localization and inner-ear expression pattern. We describe a powerful approach to identify novel genes associated with hearing and vestibular function, further increasing our understanding of the molecular biology of the inner ear.
Related Links	http://dx.doi.org/10.1007/s10162-002-2058-2
Ending Page	40
Page Count	17
Starting Page	24
File Format	PDF
ISSN	15253961
e-ISSN	14387573
Journal	JARO: Journal of the Association for Research in Otolaryngology
Issue Number	1
Volume Number	4
Language	English
Publisher	Springer-Verlag
Publisher Date	2003-02-01
Access Restriction	Open
Rights Holder	Springer-Verlag
Subject Keyword	Sensory Systems Otorhinolaryngology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Sensory Systems

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

In silico analyses of mouse inner-ear transcripts.

Sox2 and Jagged1 Expression in Normal and Drug-Damaged Adult Mouse Inner Ear

Hes5 Expression in the Postnatal and Adult Mouse Inner Ear and the Drug-Damaged Cochlea

Differential Expression of Genes within the Cochlea as Defined by a Custom Mouse Inner Ear Microarray

Conditional Gene Expression in the Mouse Inner Ear Using Cre-loxP

Sox2 Up-regulation and Glial Cell Proliferation Following Degeneration of Spiral Ganglion Neurons in the Adult Mouse Inner Ear

A Sox10rtTA/+ Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear

Expression of Aquaporin 1 and 5 in the Developing Mouse Inner Ear and Audiovestibular Assessment of an Aqp5 Null Mutant

Immortalized Mouse Inner Ear Cell Lines Demonstrate a Role for Chemokines in Promoting the Growth of Developing Statoacoustic Ganglion Neurons

In Silico Analyses of Mouse Inner-Ear Transcripts

Similar Documents

In silico analyses of mouse inner-ear transcripts.

Sox2 and Jagged1 Expression in Normal and Drug-Damaged Adult Mouse Inner Ear

Hes5 Expression in the Postnatal and Adult Mouse Inner Ear and the Drug-Damaged Cochlea

Differential Expression of Genes within the Cochlea as Defined by a Custom Mouse Inner Ear Microarray

Conditional Gene Expression in the Mouse Inner Ear Using Cre-loxP

Sox2 Up-regulation and Glial Cell Proliferation Following Degeneration of Spiral Ganglion Neurons in the Adult Mouse Inner Ear

A Sox10rtTA/+ Mouse Line Allows for Inducible Gene Expression in the Auditory and Balance Organs of the Inner Ear

Expression of Aquaporin 1 and 5 in the Developing Mouse Inner Ear and Audiovestibular Assessment of an Aqp5 Null Mutant

Immortalized Mouse Inner Ear Cell Lines Demonstrate a Role for Chemokines in Promoting the Growth of Developing Statoacoustic Ganglion Neurons

In Silico Analyses of Mouse Inner-Ear Transcripts