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| Content Provider | PubMed Central |
|---|---|
| Author | Varela, Mariana Landskron, Lisa Lai, Rachel P. J. Mckinley, Trevelyan J. Bogers, Willy M. Verschoor, Ernst J. Rob, Dubbes Barnett, Susan W. Frost, Simon D. W. Heeney, Jonathan L. |
| Copyright Year | 2011 |
| Abstract | Since the demonstration that almost 80% of human immunodeficiency virus type 1 (HIV-1) infections result from the transmission of a single variant from the donor, biological features similar to those of HIV mucosal transmission have been reported for macaques inoculated with simian immunodeficiency virus (SIV). Here we describe the early diversification events and the impact of challenge doses on viral kinetics and on the number of variants transmitted in macaques infected with the chimeric simian/human immunodeficiency virus SHIVsf162p4. We show that there is a correlation between the dose administered and the number of variants transmitted and that certain inoculum variants are preferentially transmitted. This could provide insight into the viral determinants of transmission and could aid in vaccine development. Challenge through the mucosal route with high doses results in the transmission of multiple variants in all the animals. Such an unrealistic scenario could underestimate potential intervention measures. We thus propose the use of molecular evolution analysis to aid in the determination of challenge doses that better mimic the transmission dynamics seen in natural HIV-1 infection. |
| Related Links | http://dx.doi.org/10.1128/jvi.05290-11 |
| Ending Page | 10345 |
| Page Count | 14 |
| Starting Page | 10332 |
| File Format | |
| ISSN | 0022538X |
| e-ISSN | 10985514 |
| Journal | Journal of Virology |
| Issue Number | 19 |
| Volume Number | 85 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2011-10-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Immunology Virology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology Insect Science |
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