NDLI: IL-12 selectively programs effector pathways that are stably expressed in human CD8+ effector memory T cells in vivo

Content Provider	PubMed Central
Author	Chowdhury, Fatema Z. Ramos, Hilario J. Davis, Laurie S. Forman, James Farrar, J. David
Copyright Year	2011
Abstract	CD8+ cytotoxic T lymphocytes play a major role in defense against intracellular pathogens, and their functions are specified by antigen recognition and innate cytokines. IL-12 and IFN-α/β are potent “signal 3” cytokines that are involved in both effector and memory cell development. Although the majority of effector cells are eliminated as inflammation resolves, some survive within the pool of memory cells and retain immediate effector function. In this study, we demonstrate that IL-12 instructs a unique program of effector cell differentiation that is distinct from IFN-α/β. Moreover, effector memory (TEM) cells within peripheral blood display many common attributes of cells differentiated in vitro in response to IL-12, including proinflammatory cytokine secretion and lytic activity. A pattern of IL-12–induced genes was identified that demarcate TEM from central memory cells, and the ontologies of these genes correlated precisely with their effector functions. Further, we uncovered a unique program of gene expression that was acutely regulated by IL-12 and reflected in stable gene expression patterns within TEM, but not T central memory cells in vivo. Thus, this study directly links a selective set of IL-12–induced genes to the programming of effector functions within the stable population of human CD8+ TEM cells in vivo.
Related Links	http://dx.doi.org/10.1182/blood-2011-05-357111
Ending Page	3900
Page Count	11
Starting Page	3890
File Format	PDF
ISSN	00064971
e-ISSN	15280020
Journal	Blood
Issue Number	14
Volume Number	118
Language	English
Publisher	American Society of Hematology
Publisher Date	2011-10-06
Access Restriction	Open
Rights Holder	American Society of Hematology
Subject Keyword	Immunology Cell Biology Biochemistry Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Hematology Biochemistry Immunology

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