NDLI: Dietary fenugreek and onion attenuate cholesterol gallstone formation in lithogenic diet

Content Provider	PubMed Central
Author	Reddy, Raghunatha R. L. Srinivasan, Krishnapura
Copyright Year	2011
Abstract	An animal study was conducted to evaluate the antilithogenic effect of a combination of dietary fenugreek seeds and onion. Lithogenic conditions were induced in mice by feeding them a high (0.5%) cholesterol diet (HCD) for 10 weeks. Fenugreek (12%) and onion (2%) were included individually and in combination in this HCD. Fenugreek, onion and their combination reduced the incidence of cholesterol gallstones by 75%, 27% and 76%, respectively, with attendant reduction in total cholesterol content by 38–42%, 50–72% and 61–80% in serum, liver and bile respectively. Consequently, the cholesterol/phospholipid ratio was reduced significantly in serum, liver and bile. The cholesterol saturation index of bile was reduced from 4.14 to 1.38 by the combination of fenugreek and onion and to 2.33 by onion alone. The phospholipid and bile acid contents of the bile were also increased. Changes in the hepatic enzyme activities (3-hydroxy-3-methylglutaryl Coenzyme A reductase, cholesterol-7α-hydroxylase and cholesterol-27-hydroxylase) induced by HCD were countered by fenugreek, onion and their combination. Hepatic lipid peroxides were reduced by 19–22% and 39–45% with fenugreek, onion and their combination included in the diet along with the HCD. Increased accumulation of fat in the liver and inflammation of the gallbladder membrane produced by HCD were reduced by fenugreek, onion and their combination. The antilithogenic influence was highest with fenugreek alone, and the presence of onion along with it did not further increase this effect. There was also no additive effect of the two spices in the recovery of antioxidant molecules or in the antioxidant enzyme activities.
Related Links	http://dx.doi.org/10.1111/j.1365-2613.2011.00782.x
Ending Page	319
Page Count	12
Starting Page	308
File Format	PDF
ISSN	09599673
e-ISSN	13652613
Journal	International Journal of Experimental Pathology
Issue Number	5
Volume Number	92
Language	English
Publisher	Blackwell Publishing Ltd
Publisher Date	2011-10-01
Access Restriction	Open
Rights Holder	Blackwell Publishing Ltd
Subject Keyword	Pathology and Forensic Medicine Cell Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology Pathology and Forensic Medicine

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