NDLI: Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases

Content Provider	PubMed Central
Author	Sharma, Sudha
Copyright Year	2011
Abstract	In addition to the canonical B-form structure first described by Watson and Crick, DNA can adopt a number of alternative structures. These non-B-form DNA secondary structures form spontaneously on tracts of repeat sequences that are abundant in genomes. In addition, structured forms of DNA with intrastrand pairing may arise on single-stranded DNA produced transiently during various cellular processes. Such secondary structures have a range of biological functions but also induce genetic instability. Increasing evidence suggests that genomic instabilities induced by non-B DNA secondary structures result in predisposition to diseases. Secondary DNA structures also represent a new class of molecular targets for DNA-interactive compounds that might be useful for targeting telomeres and transcriptional control. The equilibrium between the duplex DNA and formation of multistranded non-B-form structures is partly dependent upon the helicases that unwind (resolve) these alternate DNA structures. With special focus on tetraplex, triplex, and cruciform, this paper summarizes the incidence of non-B DNA structures and their association with genomic instability and emphasizes the roles of RecQ-like DNA helicases in genome maintenance by resolution of DNA secondary structures. In future, RecQ helicases are anticipated to be additional molecular targets for cancer chemotherapeutics.
Related Links	http://dx.doi.org/10.4061/2011/724215
Starting Page	724215
File Format	PDF
ISSN	2090021X
e-ISSN	2090021X
Journal	Journal of Nucleic Acids
Volume Number	2011
Language	English
Publisher	SAGE-Hindawi Access to Research
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	SAGE-Hindawi Access to Research
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Biochemistry Molecular Biology

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