NDLI: Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway

Content Provider	PubMed Central
Author	Luo, Haitao Rankin, Gary O. Juliano, Noelle Jiang, Bing-hua Chen, Yi Charlie
Copyright Year	2011
Abstract	Kaempferol has been reported to reduce the risk of ovarian cancer, but the mechanism is not completely understood. In this study, we tend to expand our understanding on how kaempferol regulates VEGF expression and angiogenesis in ovarian cancer cells. We timed VEGF secretion, and studied in-vitro angiogenesis by kaempferol treatment. Gene expression was examined by qRT-PCR, ELISA, Western Blotting, or luciferase assay, and pathways were examined by manipulating genetic components with plasmid or siRNA transfection. It was found that kaempferol time-dependently inhibited VEGF secretion, and suppressed in-vitro angiogenesis. Kaempferol down-regulated ERK phosphorelation as well as NFκB and cMyc expression, but promoted p21 expression. Examination of relationship between these genes suggested a novel ERK-NFκB-cMyc-p21-VEGF pathway, which accounts for kaempferol’s angioprevention effects in ovarian cancer cells. This data supplements our comprehension of the mechanisms behind kaempferol’s biological influence in ovarian cancer cells, and better characterized kaempferol toward chemoprevention.
Related Links	http://dx.doi.org/10.1016/j.foodchem.2011.07.045
Ending Page	328
Page Count	8
Starting Page	321
File Format	PDF
ISSN	03088146
Journal	Food chemistry
Issue Number	2
Volume Number	130
Language	English
Publisher Date	2012-01-01
Access Restriction	Open
Subject Keyword	Food Science Analytical Chemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Analytical Chemistry Food Science

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