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| Content Provider | PubMed Central |
|---|---|
| Author | Patterson, Heide Christine Kraus, Manfred Wang, Donghai Shahsafaei, Aliakbar Henderson, Joel M. Seagal, Jane Otipoby, Kevin L. Thai, To-ha Rajewsky, Klaus |
| Abstract | Igα serine 191 and 197 and threonine 203, which are located in proximity of the Igα immunoreceptor tyrosine based activation motif (ITAM), dampen Igα ITAM tyrosine phosphorylation. Here we show that mice with targeted mutations of Igα S191, 197 and T203 displayed elevated serum IgG2c and IgG2b concentrations and had elevated numbers of IgG2c and IgG2b secreting cells in the bone marrow. BCR induced Igα tyrosine phosphorylation was slightly increased in splenic B cells. Our results suggest that Igα serine/threonines limit formation of IgG2c and IgG2b secreting bone marrow plasma cells, possibly by fine-tuning Igα tyrosine mediated BCR signaling. |
| Related Links | http://dx.doi.org/10.4049/jimmunol.1101143 |
| Starting Page | 2853 |
| File Format | |
| ISSN | 15506606 |
| e-ISSN | 15506606 |
| Journal | Journal of immunology (Baltimore, Md. : 1950) |
| Issue Number | 6 |
| Volume Number | 187 |
| Language | English |
| Publisher Date | 2011-09-15 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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