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| Content Provider | PubMed Central |
|---|---|
| Author | Tan, Wei Zhang, Weizhou Amy, Strasner Grivennikov, Sergei Cheng, Jin Q. Hoffman, Robert M. Karin, Michael |
| Abstract | Inflammatory mechanisms influence tumor development and metastatic progression 1 . Of interest is the role of such mechanisms in metastatic spread of tumors whose etiology does not involve pre-existing inflammation or infection, such as breast and prostate cancers. We found that prostate cancer metastasis is associated with lymphocyte infiltration into advanced tumors and elevated expression of the tumor necrosis factor (TNF) family members receptor activator of NF-κB (RANK) ligand (RANKL) and lymphotoxin (LT) 2 . But the source of RANKL and its role in metastasis were not established. RANKL and its receptor RANK control proliferation of mammary lobuloalveolar cells during pregnancy 3 through activation of IκB kinase α (IKKα) 4 , a protein kinase that is required for self-renewal of mammary cancer progenitors 5 and prostate cancer metastasis 2 . We therefore examined whether RANKL, RANK and IKKα are also involved in mammary/breast cancer metastasis. Indeed, RANK signaling in mammary carcinoma cells that overexpress the ErbB2 (c-Neu) proto-oncogene 6 , which is frequently amplified in metastatic human breast cancers 7,8 , was important for pulmonary metastasis. Metastatic spread of ErbB2-transformed carcinoma cells was also dependent on CD4+CD25+ T cells, whose major pro-metastatic function appeared to be RANKL production. RANKL-producing T cells were mainly FoxP3+ and found in close proximity to smooth muscle actin (SMA)-positive stromal cells in mouse and human breast cancers. The T cell-dependence of pulmonary metastasis was replaced by administration of exogenous RANKL, a procedure that also stimulated pulmonary metastasis of RANK-positive human breast carcinoma cells. These results are consistent with the adverse prognostic impact of tumor-infiltrating CD4+ or FoxP3+ T cells on human breast cancer 9,10 and suggest that targeting of RANKL-RANK signaling can be used in conjunction with other therapies to prevent subsequent metastatic disease. |
| Related Links | http://dx.doi.org/10.1038/nature09707 |
| Starting Page | 548 |
| File Format | |
| ISSN | 14764687 |
| e-ISSN | 14764687 |
| Journal | Nature |
| Issue Number | 7335 |
| Volume Number | 470 |
| Language | English |
| Publisher Date | 2011-02-24 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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