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Homology modeling and consensus protein disorder prediction of human filamin
| Content Provider | PubMed Central |
|---|---|
| Author | Kumar, Suresh |
| Copyright Year | 2011 |
| Abstract | Filamins are dimeric actin-binding proteins participating in the organization of the actin-based cytoskeleton. Their modular domain organization is made up of anN-terminal actin-binding domain composed of two CH domains followed by flexible rod regions that consist of 24 Ig-like domains. Homology modeling was usedto model human filamin using Modeller 9v5. The resulting model assessed by Verify 3D and PROCHECK showed that the final model is reliable. Theconformational disorder prediction of human filamin residues were also mapped on the validated structure of human filamin. Prediction of protein disorder infilamin structures will help understand its role in function. |
| Ending Page | 369 |
| Starting Page | 366 |
| File Format | |
| ISSN | 09732063 |
| e-ISSN | 09732063 |
| Journal | Bioinformation |
| Issue Number | 10 |
| Volume Number | 6 |
| Language | English |
| Publisher | Biomedical Informatics |
| Access Restriction | Open |
| Rights Holder | Biomedical Informatics |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
