NDLI: Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland

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Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland

Content Provider	PubMed Central
Author	Kidd, Lacreis R. Hein, David W. Woodson, Karen Taylor, Philip R. Demetrius, Albanes Virtamo, Jarmo Tangrea, Joseph A.
Copyright Year	2010
Abstract	Genetic variations in xenobiotic metabolizing genes can influence susceptibility to many environmentally induced cancers. Inheritance of the N-acetyltransferase 1 allele (NAT110), linked with increased metabolic activation of pro-carcinogens, is associated with an increased susceptibility to many cancers in which cigarette- or meat-derived carcinogens have been implicated in their etiology. The role of NAT110 in prostate cancer is under studied. Although cigarette smoking is not considered a risk factor for prostate cancer, a recent review suggests it may play a role in disease progression. Consequently, we examined the association of NAT110 with prostate cancer risk, grade, and stage among 400 Finnish male smokers using a case–control study design. Following genotyping of 206 patients and 196 healthy controls, our results do not support the role of NAT110 in relation to prostate cancer risk (OR = 1.28; 95% CI, 0.66–2.47), aggressive disease (OR = 0.58; 95% CI, 0.13–2.67), or advanced disease (OR = 1.19; 95% CI, 0.49–2.91).
Related Links	http://dx.doi.org/10.1007/s10528-010-9386-4
Ending Page	82
Page Count	10
Starting Page	73
File Format	PDF
ISSN	00062928
e-ISSN	15734927
Journal	Biochemical genetics
Issue Number	1-2
Volume Number	49
Language	English
Publisher Date	2011-02-01
Access Restriction	Open
Subject Keyword	Genetics Biochemistry Ecology, Evolution, Behavior and Systematics Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Biochemistry Molecular Biology Ecology, Evolution, Behavior and Systematics

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Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland

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Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland

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Lack of Association of the N-acetyltransferase NAT1*10 Allele with Prostate Cancer Incidence, Grade, or Stage Among Smokers in Finland

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