NDLI: Comparative Toxicology of Mercurials in Caenorhabditis elegans

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Comparative Toxicology of Mercurials in Caenorhabditis elegans

Content Provider	PubMed Central
Author	Mcelwee, Matthew K. Freedman, Jonathan H.
Abstract	Mercury is a toxic metal that can exist in multiple chemical species. Humans are commonly exposed to methylmercury and mercury vapor, which is converted to mercuric mercury in the body. Despite years of research, there is a paucity of information on the similarity and differences in the mechanisms of mercury toxicity. The relative toxicity of mercuric chloride (HgCl2) and methylmercury chloride (MeHgCl) in C. elegans was determined using assays that measured growth, feeding, reproduction, and locomotion. The effect of HgCl2 and MeHgCl on the expression of several archetypal stress-response genes was also determined. There was no significant difference between the EC50s of the two mercurials on C. elegans growth. However, MeHgCl was more toxic to C. elegans than HgCl2 when assessing feeding, movement and reproduction, all of which require proper neuromuscular activity. Methylmercury chloride exposure resulted in increased steady-state levels of the stress response genes at lower concentrations than HgCl2. In general, MeHgCl was more toxic to C. elegans than HgCl2, particularly when assaying behaviors that require neuromuscular function.
Related Links	http://dx.doi.org/10.1002/etc.603
Ending Page	2141
Page Count	7
Starting Page	2135
File Format	PDF
ISSN	07307268
e-ISSN	15528618
Journal	Environmental toxicology and chemistry / SETAC
Issue Number	9
Volume Number	30
Language	English
Publisher Date	2011-09-01
Access Restriction	Open
Subject Keyword	Health, Toxicology and Mutagenesis Environmental Chemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

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Comparative Toxicology of Mercurials in Caenorhabditis elegans

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