NDLI: Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein

Content Provider	PubMed Central
Author	Ginger, Rebecca S. Dalton, Emma C. Ryves, W. Jonathan Fukuzawa, Masashi Williams, Jeffrey G. Harwood, Adrian J.
Copyright Year	2000
Abstract	Extracellular cAMP stimulates the rapid tyrosine phosphorylation and nuclear translocation of the Dictyostelium STAT protein Dd-STATa. Here we show that it also induces serine phosphorylation by GskA, a homologue of glycogen synthase kinase-3 (GSK-3). Tyrosine phosphorylation occurs within 10 s of stimulation, whereas serine phosphorylation takes 5 min, matching the kinetics observed for the cAMP regulation of GskA. Phosphorylation by GskA enhances nuclear export of Dd-STATa. The phosphorylated region, however, is not itself a nuclear export signal and we identify a region elsewhere in the protein that mediates nuclear export. These results suggest a biphasic regulation of Dd-STATa, in which extracellular cAMP initially directs nuclear import and then, via GskA, promotes its subsequent export. It also raises the possibility of an analogous regulation of STAT nuclear export in higher eukaryotes.
Related Links	http://dx.doi.org/10.1093/emboj/19.20.5483
Ending Page	5491
Page Count	9
Starting Page	5483
File Format	PDF
ISSN	14602075
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	20
Volume Number	19
Language	English
Publisher	Oxford University Press
Publisher Date	2000-10-16
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

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