NDLI: Differential Effects in Cardiovascular Markers between High-Dose Angiotensin II Receptor Blocker Monotherapy and Combination Therapy of ARB with Calcium Channel Blocker in Hypertension (DEAR Trial)

Content Provider	PubMed Central
Author	Kinouchi, Kenichiro Ichihara, Atsuhiro Bokuda, Kanako Kurosawa, Hideaki Itoh, Hiroshi
Copyright Year	2011
Abstract	Background/Aims. Arterial stiffness is an independent risk factor for cardiovascular morbidity and mortality. This study was conducted to determine the effect of olmesartan (OLM) and azelnidipine (AZL) on arterial stiffness using the cardio-ankle vascular index (CAVI), which is a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients. Methods. Fifty-two consecutive hypertensive patients were randomly assigned either to a group treated with OLM monotherapy or to a group treated with OLM and AZL combination therapy. Clinical and biological parameters were measured before and 12 months after the start of this study. Results. Both therapies significantly and similarly reduced BP, augmentation index, and plasma aldosterone levels. The combination therapy significantly decreased CAVI and serum low-density lipoprotein (LDL-C) levels and these reductions were significantly greater than those produced with monotherapy. No significant differences in metabolic parameters were observed between the two therapies. Conclusion. The combination therapy with OLM and AZL had beneficial effects on arterial stiffness assessed by CAVI, LDL-C, and metabolism, despite the similar BP reduction, compared with OLM monotherapy. Since these markers are known to influence the future risk of cardiovascular events, combination therapy with OLM and AZL could be a useful choice for treating hypertensive patients.
Related Links	http://dx.doi.org/10.4061/2011/284823
Starting Page	284823
File Format	PDF
ISSN	20900392
e-ISSN	20900392
Journal	International Journal of Hypertension
Volume Number	2011
Language	English
Publisher	SAGE-Hindawi Access to Research
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	SAGE-Hindawi Access to Research
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Internal Medicine

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