NDLI: Human T Cell Leukemia Virus Type 1 Tax Inhibits Innate Antiviral Signaling via NF-κB-Dependent Induction of SOCS1▿

Content Provider	PubMed Central
Author	Charoenthongtrakul, Soratree Zhou, Qinjie Shembade, Noula Harhaj, Nicole S. Harhaj, Edward W.
Copyright Year	2011
Abstract	Human T cell leukemia virus type 1 (HTLV-1) inhibits host antiviral signaling pathways although the underlying mechanisms are unclear. Here we found that the HTLV-1 Tax oncoprotein induced the expression of SOCS1, an inhibitor of interferon signaling. Tax required NF-κB, but not CREB, to induce the expression of SOCS1 in T cells. Furthermore, Tax interacted with SOCS1 in both transfected cells and in HTLV-1-transformed cell lines. Although SOCS1 is normally a short-lived protein, in the presence of Tax, the stability of SOCS1 was greatly increased. Accordingly, Tax enhanced the replication of a heterologous virus, vesicular stomatitis virus (VSV), in a SOCS1-dependent manner. Surprisingly, Tax required SOCS1 to inhibit RIG-I-dependent antiviral signaling, but not the interferon-induced JAK/STAT pathway. Inhibition of SOCS1 by RNA-mediated interference in the HTLV-1-transformed cell line MT-2 resulted in increased IFN-β expression accompanied by reduced HTLV-1 replication and p19Gag levels. Taken together, our results reveal that Tax inhibits antiviral signaling, in part, by hijacking an interferon regulatory protein.
Related Links	http://dx.doi.org/10.1128/jvi.00007-11
Ending Page	6962
Page Count	8
Starting Page	6955
File Format	PDF
ISSN	0022538X
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	14
Volume Number	85
Language	English
Publisher	American Society for Microbiology
Publisher Date	2011-07-15
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Immunology Virology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1

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