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  1. Therapeutic Advances in Medical Oncology
  2. Year: 2011, Volume: 3
  3. Year: 2011, Volume: 3, Issue: 2
  4. Sipuleucel-T in patients with metastatic castration-resistant prostate cancer: an insight for oncologists
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Year: 2016, Volume: 8
Year: 2015, Volume: 8
Year: 2015, Volume: 7
Year: 2014, Volume: 6
Year: 2013, Volume: 5
Year: 2012, Volume: 4
Year: 2011, Volume: 3
Year: 2011, Volume: 3, Issue: 6
Year: 2011, Volume: 3, Issue: 5
Year: 2011, Volume: 3, Issue: 4
Year: 2011, Volume: 3, Issue: 3
Year: 2011, Volume: 3, Issue: 2
Health-related quality of life and cancer clinical trials
Bevacizumab in metastatic breast cancer: when may it be used?
Enhancing the clinical activity of sorafenib through dose escalation: rationale and current experience
Sipuleucel-T in patients with metastatic castration-resistant prostate cancer: an insight for oncologists
Year: 2011, Volume: 3, Issue: 1 Suppl
Year: 2011, Volume: 3, Issue: 1
Year: 2010, Volume: 2
Year: 2009, Volume: 1

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Sipuleucel-T in patients with metastatic castration-resistant prostate cancer: an insight for oncologists

Content Provider PubMed Central
Author Garcia, Jorge A.
Copyright Year 2011
Abstract Sipuleucel-T represents a novel immunotherapeutic compound designed to stimulate an immune response against castration-resistant prostate cancer (CRPC). Sipuleucel-T is an autologous active cellular immunotherapy product, which includes autologous dendritic cells pulsed ex vivo with PAP2024, a recombinant fusion protein made of prostatic acid phosphatase and granulocyte-macrophage colony-stimulating factor. Despite the lack of prostate-specific antigen and objective response, a recent phase III randomized trial demonstrated a significant improvement in overall survival in asymptomatic and minimally symptomatic CRPC patients. This review summarizes the clinical development of Sipuleucel-T in CRPC that led to the regulatory approval of this compound in the USA.
Related Links http://dx.doi.org/10.1177/1758834010397692
Starting Page 101
File Format PDF
ISSN 17588340
e-ISSN 17588359
Journal Therapeutic Advances in Medical Oncology
Issue Number 2
Volume Number 3
Language English
Publisher SAGE Publications
Publisher Date 2011-02-01
Access Restriction Open
Rights Holder SAGE Publications
Subject Keyword Oncology Research in Higher Education
Content Type Text
Resource Type Article
Subject Oncology
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