NDLI: Intravascular Glucose/Lactate Sensors Prepared with Nitric Oxide Releasing Poly(lactide-co-glycolide)-Based Coatings for Enhanced Biocompatibility

Content Provider	PubMed Central
Author	Yan, Qinyi Major, Terry C. Bartlett, Robert H. Meyerhoff, Mark E.
Copyright Year	2011
Abstract	Intravenous amperometric needle-type enzymatic glucose/lactate sensors intended for continuous monitoring are prepared with a novel nitric oxide (NO) releasing layer to improve device hemocompatibility. To create an underlying NO release coating, the sensors with immobilized enzymes (either glucose oxidase or lactate oxidase) are prepared with a thin layer of poly(lactide-co-glycolide) (PLGA) loaded with lipophilic diazeniumdiolate species that slowly release NO via a proton driven reaction. An outer thin layer (ca. 30 µm) of PurSil (polyurethane/dimethylsiloxane copolymer) limits the flux of glucose and lactate to the inner layer of enzyme, to provide the desired linear amperometric response. A 30 µm coating of PLGA containing 33 wt% of the appropriate NO donor (N-diazeniumdiolated dibutylhexanediamine, DBHD/N2O2) can release NO at a physiologically relevant rate > 1 × 10−10 mol min−1cm−2 for at least 7 d without influencing the analytical performance of the glucose/lactate sensors. In vitro, the sensors exhibit relatively stable amperometric response over a one-week period with high selectivity over interferences (e.g., ascorbic acid) required for blood monitoring applications. Glucose sensors implanted in the veins of rabbits for 8 h exhibit significantly enhanced hemocompatibility for the NO release sensors vs. corresponding controls (without NO release in same animals), with greatly reduced thrombus formation on their surfaces. Further, the analytical performance of the NO release glucose sensors are superior to controls placed in the veins of the same animals, with a greater accuracy in measuring blood glucose levels as evaluated using a Clark error grid type analysis.
Related Links	http://dx.doi.org/10.1016/j.bios.2011.04.026
Ending Page	4282
Page Count	7
Starting Page	4276
File Format	PDF
ISSN	09565663
e-ISSN	18734235
Journal	Biosensors & bioelectronics
Issue Number	11
Volume Number	26
Language	English
Publisher Date	2011-07-01
Access Restriction	Open
Subject Keyword	Biotechnology Biophysics Electrochemistry Biomedical Engineering Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Medicine Biophysics Biomedical Engineering Biotechnology Electrochemistry

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