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| Content Provider | PubMed Central |
|---|---|
| Author | Perez, Sylvia E. Berg, Brian M. Moore, Kenneth A. He, Bin Counts, Scott E. Fritz, Jason J. Hu, Yuan-shih Lazarov, Orly Lah, James J. Mufson, Elliott J. |
| Abstract | Epidemiological and clinical trial findings suggest that consumption of docosahexaenoic acid (DHA) lowers the risk of Alzhemier’s disease (AD). We examined the effects of short-term (3 months) DHA enriched diet on plaque deposition and synaptic deficts in forebrain of young APPswe/PS1ΔE9 transgenic (tg) and non-transgenic (ntg) mice. Gas chromatography revealed a significant increase in DHA concomitant with a decrease of arachidonic acid in both brain and liver in mice fed with DHA. Female tg mice consumed relatively more food daily than ntg female mice, independent of diet. Plaque load was significantly reduced in the cortex, ventral hippocampus and striatum of female APPswe/PS1ΔE9 tg mice on DHA diet compared to female tg mice on control diet. LR11 levels were unchanged in mice on DHA. Moreover drebrin levels were significantly increased in the hippocampus of tg mice on the DHA diet. Finally, in vitro DHA treatment prevented amyloid toxicity in cell cultures. Our findings support the concept that increased DHA consumption may play and important role in preventing brain insults in AD. |
| Related Links | http://dx.doi.org/10.1002/jnr.22266 |
| Starting Page | 1026 |
| File Format | |
| ISSN | 10974547 |
| e-ISSN | 10974547 |
| Journal | Journal of neuroscience research |
| Issue Number | 5 |
| Volume Number | 88 |
| Language | English |
| Publisher Date | 2010-04-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cellular and Molecular Neuroscience |
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