NDLI: Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation

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Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation

Content Provider	PubMed Central
Author	Chernoff, Jonathan Shepelev, Mikhail V. Korobko, Igor V.
Copyright Year	2011
Abstract	Rho GTPases regulate numerous cellular processes including apoptosis. Chp/RhoV is an atypical Rho GTPase which functions are poorly understood. Here we investigated the role of Chp in regulation of cell viability using PC12 cells with inducible expression of Chp as a model. We found that expression of Chp results in apoptosis in PC12 cells. Chp-induced apoptosis was accompanied by activation of JNK signaling and both death receptor-mediated and mitochondrial apoptotic pathways as justified by caspase-8 and caspase-9 activation, respectively. Moreover, inhibition of JNK by SP600125 rescued PC12 cells from Chp-triggered cell death and attenuated activation of caspases-9 and -3/7 suggesting that activation of JNK mediates pro-apoptotic effect of Chp. Expression of Chp resulted in increased phosphorylation of c-Jun in PC12 cells, and Chp expression in HE K293 cells upregulated AP-1-dependent transcription in a JNK-dependent manner. Together results of our study reveal the role of Chp GTPase as a putative regulator of JNK-dependent apoptotic death in PC12 cells, similarly to previously described pro-apoptotic activity of the related Cdc42 and Rac1 GTPases.
Related Links	http://dx.doi.org/10.4161/sgtp.2.1.15229
Ending Page	26
Page Count	10
Starting Page	17
File Format	PDF
ISSN	21541248
e-ISSN	21541256
Journal	Small GTPases
Issue Number	1
Volume Number	2
Language	English
Publisher	Landes Bioscience
Publisher Date	2011-01-01
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Biomaterials Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry

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