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| Content Provider | PubMed Central |
|---|---|
| Author | Kim, Joon Mee Cho, Mee-yon Sohn, Jin Hee Kang, Dae Young Park, Cheol Keun Kim, Woo Ho Jin, So-young Kim, Kyoung Mee Chang, Hee Kyung Yu, Eunsil Jung, Eun Sun Chang, Mee Soo Joo, Jong Eun Joo, Mee Kim, Youn Wha Park, Do Youn Kang, Yun Kyung Park, Sun Hoo Han, Hye Seung Kim, Young Bae Park, Ho Sung Chae, Yang Seok Kwon, Kye Won Chang, Hee Jin |
| Copyright Year | 2011 |
| Description | The Gastrointestinal Pathology Study Group of Korean Society of Pathologists |
| Abstract | The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important, but the diagnostic criteria, terminology, and grading system are not the same in the East and West. A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists, but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion. Although the Vienna classification was introduced to reduce diagnostic discrepancies, it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions. Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine. Japan is geographically close to Korea, and academic exchanges are active. Additionally, Korean doctors are familiar with Western style medical terminology. As a result, the terminology, definitions, and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea. To solve this problem, the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis: (1) a diagnosis of carcinoma is based on invasion; (2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching, budding, or marked glandular crowding; (3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts, the lesion is considered high grade dysplasia; (4) if severe cytologic atypia is present, careful inspection for invasive foci is necessary, because the risk for invasion is very high; and (5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern, papillae, ridges, vesicular nuclei, high nuclear/cytoplasmic ratio, loss of nuclear polarity, thick and irregular nuclear membrane, and nucleoli. |
| Related Links | http://dx.doi.org/10.3748/wjg.v17.i21.2602 |
| Starting Page | 2602 |
| File Format | |
| ISSN | 10079327 |
| Journal | World Journal of Gastroenterology : WJG |
| Issue Number | 21 |
| Volume Number | 17 |
| Language | English |
| Publisher | Baishideng Publishing Group Co., Limited |
| Publisher Date | 2011-01-01 |
| Access Restriction | Open |
| Rights Holder | Baishideng Publishing Group Co., Limited |
| Subject Keyword | Gastroenterology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
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