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Is PiSS Alpha-1 Antitrypsin Deficiency Associated with Disease?
| Content Provider | PubMed Central |
|---|---|
| Author | Mcgee, Dawn Schwarz, Laura Mcclure, Rebecca Peterka, Lauren Rouhani, Farshid Brantly, Mark Strange, Charlie |
| Copyright Year | 2010 |
| Abstract | Background. Alpha-1 antitrypsin deficiency (AAT) is an inherited condition that predisposes to lung and/or liver disease. Objective. The current study examined the clinical features of the PiSS genotype. Methods. Nineteen study participants (PiSS) and 29 matched control participants (PiMM) were telephone interviewed using a standardized questionnaire. Demographic features, cigarette smoking, vocation, medication history, and clinical diagnoses were compared. Statistical analysis was performed. Finally, a comprehensive literature review was performed by two investigators. Results. 12/19 (63.2%) study participants reported the presence of lung and/or liver disease compared to 12/29 (41.4%) control participants. There trended toward having a higher frequency of medication allergies in the study population (42.11% versus 20.69%). Conclusions. The PiSS genotype was associated with a similar incidence of obstructive lung disease to controls. Selective bias intrinsic in testing for AAT deficiency and the rarity of the PiSS genotype will make future study of this association dependent on population-based tests. |
| Related Links | http://dx.doi.org/10.1155/2010/570679 |
| Starting Page | 570679 |
| File Format | |
| ISSN | 20901836 |
| e-ISSN | 20901844 |
| Journal | Pulmonary Medicine |
| Volume Number | 2010 |
| Language | English |
| Publisher | Hindawi Publishing Corporation |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Rights Holder | Hindawi Publishing Corporation |
| Subject Keyword | Pulmonary Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine |
