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| Content Provider | PubMed Central |
|---|---|
| Author | Johnson, Philip L. F. Kochin, Beth F. Mcafee, Megan S. Stromnes, Ingunn M. Regoes, Roland R. Ahmed, Rafi Blattman, Joseph N. Antia, Rustom |
| Copyright Year | 2011 |
| Abstract | While T cell-based vaccines have the potential to provide protection against chronic virus infections, they also have the potential to generate immunopathology following subsequent virus infection. We develop a mathematical model to investigate the conditions under which T cells lead to protection versus adverse pathology. The model illustrates how the balance between virus clearance and immune exhaustion may be disrupted when vaccination generates intermediate numbers of specific CD8 T cells. Surprisingly, our model suggests that this adverse effect of vaccination is largely unaffected by the generation of mutant viruses that evade T cell recognition and cannot be avoided by simply increasing the quality (affinity) or diversity of the T cell response. These findings should be taken into account when developing vaccines against persistent infections. |
| Related Links | http://dx.doi.org/10.1128/JVI.00166-11 |
| Starting Page | 5565 |
| File Format | |
| ISSN | 10985514 |
| e-ISSN | 10985514 |
| Journal | Journal of Virology |
| Issue Number | 11 |
| Volume Number | 85 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2011-06-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Immunology Microbiology Insect Science |
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