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| Content Provider | PubMed Central |
|---|---|
| Author | Steding, Catherine E. Wu, Sung-tse Zhang, Yanping Jeng, Meei-huey Elzey, Bennett D. Kao, Chinghai |
| Abstract | Myeloid-derived suppressor cells (MDSC) are important to the tumour microenvironment as they actively suppress the immune system and promote tumour progression and metastasis. These cells block T-cell activation in the tumour microenvironment, preventing anti-tumour immune activity. The ability of a treatment to alter the suppressive function of these cells and promote an immune response is essential to enhancing overall therapeutic efficacy. Interleukin-12 (IL-12) has the potential not only to promote anti-tumour immune responses but also to block the activity of cells capable of immune suppression. This paper identifies a novel role for IL-12 as a modulator of MDSC activity, with implications for IL-12 as a therapeutic agent. Treatment with IL-12 was found to alter the suppressive function of MDSC by fundamentally altering the cells. Interleukin-12-treated MDSC exhibited up-regulation of surface markers indicative of mature cells as well as decreases in nitric oxide synthase and interferon-γ mRNA both in vitro and in vivo. Treatment with IL-12 was also found to have significant therapeutic benefit by decreasing the percentage of MDSC in the tumour microenvironment and increasing the percentage of active CD8+ T cells. Treatment with IL-12 resulted in an increase in overall survival accompanied by a reduction in metastasis. The findings in this paper identify IL-12 as a modulator of immune suppression with significant potential as a therapeutic agent for metastatic breast cancer. |
| Related Links | http://dx.doi.org/10.1111/j.1365-2567.2011.03429.x |
| Ending Page | 238 |
| Page Count | 18 |
| Starting Page | 221 |
| File Format | |
| ISSN | 00192805 |
| e-ISSN | 13652567 |
| Journal | Immunology |
| Issue Number | 2 |
| Volume Number | 133 |
| Language | English |
| Publisher | Blackwell Science Inc |
| Publisher Date | 2011-06-01 |
| Access Restriction | Open |
| Rights Holder | Blackwell Science Inc |
| Subject Keyword | Immunology Immunology and Allergy Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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