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Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment
| Content Provider | PubMed Central |
|---|---|
| Author | Radziejewska, Iwona Borzym-kluczyk, Małgorzata Namiot, Zbigniew Stefańska, Ewa |
| Abstract | It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of glycoproteins of gastric juice before and at the end of eradication therapy. Gastric juices were taken from 13 clinical patients and subjected to analysis. Pooled fractions of the void volume obtained after gel filtration were subjected to ELISA tests. To assess the relative amounts of carbohydrate structures, lectins and monoclonal antibodies were used. Changes in the level of MUC 1 and MUC 5AC mucins and of carbohydrate structures, which are suggested to be receptors for Helicobacter pylori adhesins, were observed by the end of the eradication treatment. Our results support the idea about the involvement of MUC 5AC and MUC 1 with some specific sugar structures in the mechanism of Helicobacter pylori infection. |
| Related Links | http://dx.doi.org/10.1007/s10238-010-0113-6 |
| Ending Page | 88 |
| Page Count | 8 |
| Starting Page | 81 |
| File Format | |
| ISSN | 15918890 |
| e-ISSN | 15919528 |
| Journal | Clinical and Experimental Medicine |
| Issue Number | 2 |
| Volume Number | 11 |
| Language | English |
| Publisher | Springer Milan |
| Publisher Date | 2011-06-01 |
| Access Restriction | Open |
| Rights Holder | Springer Milan |
| Subject Keyword | Biochemistry, Genetics and Molecular Biology(all) Medicine(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Biochemistry, Genetics and Molecular Biology |
