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| Content Provider | PubMed Central |
|---|---|
| Author | Hadidi, Naghmeh Kobarfard, Farzad Nafissi-varcheh, Nastaran Reza, Aboofazeli |
| Copyright Year | 2011 |
| Abstract | In this study, noncovalent functionalization of single-walled carbon nanotubes (SWCNTs) with phospholipid-polyethylene glycols (Pl-PEGs) was performed to improve the solubility of SWCNTs in aqueous solution. Two kinds of PEG derivatives, ie, Pl-PEG 2000 and Pl-PEG 5000, were used for the PEGylation process. An experimental design technique (D-optimal design and second-order polynomial equations) was applied to investigate the effect of variables on PEGylation and the solubility of SWCNTs. The type of PEG derivative was selected as a qualitative parameter, and the PEG/SWCNT weight ratio and sonication time were applied as quantitative variables for the experimental design. Optimization was performed for two responses, aqueous solubility and loading efficiency. The grafting of PEG to the carbon nanostructure was determined by thermogravimetric analysis, Raman spectroscopy, and scanning electron microscopy. Aqueous solubility and loading efficiency were determined by ultraviolet-visible spectrophotometry and measurement of free amine groups, respectively. Results showed that Pl-PEGs were grafted onto SWCNTs. Aqueous solubility of 0.84 mg/mL and loading efficiency of nearly 98% were achieved for the prepared Pl-PEG 5000-SWCNT conjugates. Evaluation of functionalized SWCNTs showed that our noncovalent functionalization protocol could considerably increase aqueous solubility, which is an essential criterion in the design of a carbon nanotube-based drug delivery system and its biodistribution. |
| Related Links | http://dx.doi.org/10.2147/ijn.s17626 |
| Ending Page | 746 |
| Starting Page | 737 |
| File Format | |
| ISSN | 11782013 |
| e-ISSN | 11782013 |
| Journal | International Journal of Nanomedicine |
| Volume Number | 6 |
| Language | English |
| Publisher | Dove Medical Press |
| Publisher Date | 2011-04-01 |
| Access Restriction | Open |
| Rights Holder | Dove Medical Press |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Organic Chemistry Medicine Drug Discovery Biomaterials Biophysics Bioengineering Pharmaceutical Science |
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