NDLI: DNA polymerase III α subunit from Mycobacterium tuberculosis H37Rv: Homology modeling and molecular docking of its inhibitor

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DNA polymerase III α subunit from Mycobacterium tuberculosis H37Rv: Homology modeling and molecular docking of its inhibitor

Content Provider	PubMed Central
Author	Chhabra, Gagan Dixit, Aparna Lalit, C. Garg
Copyright Year	2011
Abstract	The alpha subunit of Mycobacterial DNA polymerase III holo enzyme catalyzes the polymerization of both DNA strands. The present investigation reports threedimensional (3-D) structure model of DNA polymerase III α subunit of Mycobacterium tuberculosis H37Rv (MtbDnaE1) generated using homology modelingwith the backbone structure of DNA polymerase III α of Thermus aquaticus as a template. The model was evaluated at various structure verification servers,which assess the stereo chemical parameters of the residues in the model, as well as structural and functional domains. Comparative analysis of MtbDnaE1structure reveals the structure of its catalytic domain to be unrelated to that of the human. Successful docking of known inhibitor of bacterial DNA polymerases,251D onto the modeled MtbDnaE1 was also performed. Therefore, the structure model of MtbDnaE1, a potential anti-mycobacterial target, opens a new avenuefor structure-based drug designing against the pathogen.
Ending Page	73
Starting Page	69
File Format	PDF
ISSN	09732063
e-ISSN	09732063
Journal	Bioinformation
Issue Number	2
Volume Number	6
Language	English
Publisher	Biomedical Informatics
Publisher Date	2011-03-26
Access Restriction	Open
Rights Holder	Biomedical Informatics
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article

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