NDLI: The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development

Content Provider	PubMed Central
Author	Anderson, Aimée E. Karandikar, Umesh C. Pepple, Kathryn L. Chen, Zhihong Bergmann, Andreas Mardon, Graeme
Copyright Year	2011
Abstract	In vitro data suggest that the human RbAp46 and RbAp48 genes encode proteins involved in multiple chromatin remodeling complexes and are likely to play important roles in development and tumor suppression. However, to date, our understanding of the role of RbAp46/RbAp48 and its homologs in metazoan development and disease has been hampered by a lack of insect and mammalian mutant models, as well as redundancy due to multiple orthologs in most organisms studied. Here, we report the first mutations in the single Drosophila RbAp46/RbAp48 homolog Caf1, identified as strong suppressors of a senseless overexpression phenotype. Reduced levels of Caf1 expression result in flies with phenotypes reminiscent of Hox gene misregulation. Additionally, analysis of Caf1 mutant tissue suggests that Caf1 plays important roles in cell survival and segment identity, and loss of Caf1 is associated with a reduction in the Polycomb Repressive Complex 2 (PRC2)-specific histone methylation mark H3K27me3. Taken together, our results suggest suppression of senseless overexpression by mutations in Caf1 is mediated by participation of Caf1 in PRC2-mediated silencing. More importantly, our mutant phenotypes confirm that Caf1-mediated silencing is vital to Drosophila development. These studies underscore the importance of Caf1 and its mammalian homologs in development and disease.
Related Links	http://dx.doi.org/10.1242/dev.058461
Ending Page	1966
Page Count	10
Starting Page	1957
File Format	PDF
ISSN	09501991
e-ISSN	14779129
Journal	Development (Cambridge, England)
Issue Number	10
Volume Number	138
Language	English
Publisher	Company of Biologists
Publisher Date	2011-05-15
Access Restriction	Open
Rights Holder	Company of Biologists
Subject Keyword	Developmental Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Molecular Biology

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