NDLI: Fungal pathogen recognition by scavenger receptors in nematodes and mammals

Content Provider	PubMed Central
Author	Means, Terry K.
Copyright Year	2010
Abstract	Macrophages are important cells in the host resistance to fungal infections, and fungal recognition by macrophages triggers phagocytosis, intracellular killing, induction of inflammatory cytokines and chemokines, and initiation of the adaptive immune response. All of the receptors that mediate binding and engulfment of fungal pathogens and the signaling pathways triggered by fungal pathogens that regulate anti-fungal immunity are not fully understood. Using an RNAi screen we recently demonstrated that the C. elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 and CD36 mediate host defense against the fungal pathogen, Cryptococcus neoformans. Finally, SCARF1 and CD36 function as co-receptors by binding and engulfing fungal pathogens to facilitate Toll-like receptor 2 signaling. Here we will summarize and expand upon our previous findings.
Related Links	http://dx.doi.org/10.4161/viru.1.1.10228
Ending Page	41
Page Count	5
Starting Page	37
File Format	PDF
ISSN	21505594
e-ISSN	21505608
Journal	Virulence
Issue Number	1
Volume Number	1
Language	English
Publisher	Landes Bioscience
Publisher Date	2010-01-01
Access Restriction	Open
Rights Holder	Landes Bioscience
Subject Keyword	Immunology Microbiology (medical) Microbiology Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology Microbiology (medical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Regulation of phenotypic transitions in the fungal pathogen Candida albicans

Scavenger Receptor A Dampens Induction of Inflammation in Response to the Fungal Pathogen Pneumocystis carinii ▿

The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans

The role of pattern recognition receptors in the innate recognition of Candida albicans

Recognition of Corynebacterium pseudodiphtheriticum by Toll-like receptors and up-regulation of antimicrobial peptides in human corneal epithelial cells

The fungal UPR

Secreted Dipeptidyl Peptidase IV Activity in the Dimorphic Fungal Pathogen Histoplasma capsulatum ▿

Secretion stress and fungal pathogenesis

Elucidating the Pathogenesis of Spores from the Human Fungal Pathogen Cryptococcus neoformans ▿

Fungal pathogen recognition by scavenger receptors in nematodes and mammals

Similar Documents

Regulation of phenotypic transitions in the fungal pathogen Candida albicans

Scavenger Receptor A Dampens Induction of Inflammation in Response to the Fungal Pathogen Pneumocystis carinii ▿

The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans

The role of pattern recognition receptors in the innate recognition of Candida albicans

Recognition of Corynebacterium pseudodiphtheriticum by Toll-like receptors and up-regulation of antimicrobial peptides in human corneal epithelial cells

The fungal UPR

Secreted Dipeptidyl Peptidase IV Activity in the Dimorphic Fungal Pathogen Histoplasma capsulatum ▿

Secretion stress and fungal pathogenesis

Elucidating the Pathogenesis of Spores from the Human Fungal Pathogen Cryptococcus neoformans ▿

Fungal pathogen recognition by scavenger receptors in nematodes and mammals