NDLI: Reorganization of the Primary Motor Cortex of Adult Macaque Monkeys After Sensory Loss Resulting From Partial Spinal Cord Injuries

Content Provider	PubMed Central
Author	Kambi, Niranjan Tandon, Shashank Hisham, Md Lazar, Leslee Jain, Neeraj
Abstract	Long-term injuries to the dorsal columns of the spinal cord at cervical levels result in large-scale somatotopic reorganization of the somatosensory areas of the cortex and the ventroposterior nucleus of the thalamus. As a result of this reorganization intact inputs from the face expand into the deafferented hand representations. Dorsal column injuries also result in permanent deficits in the use of digits for precision grip and a loss of fractionated movements of the digits. We determined if the chronic loss of sensory inputs and the behavioral deficits caused by lesions of the dorsal columns in adult macaque monkeys affect organization of the motor cortex. The results show that in the primary motor cortex, intracortical microstimulation evokes extension-flexion movements of the thumb at significantly fewer sites as compared to the normal monkeys. There is a corresponding increase in the adduction-abduction movements. Furthermore, there is a significant increase in the thresholds of the currents required to evoke movements of the digits. Thus, long-term sensory loss in adult monkeys does not change the overall topography of the movement representation in the motor cortex but results in changes in the details of movement representations.
Related Links	http://dx.doi.org/10.1523/jneurosci.5187-10.2011
Ending Page	3707
Page Count	12
Starting Page	3696
File Format	PDF
ISSN	02706474
e-ISSN	15292401
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Issue Number	10
Volume Number	31
Language	English
Publisher Date	2011-03-09
Access Restriction	Open
Subject Keyword	Neuroscience(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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