NDLI: Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner

Content Provider	PubMed Central
Author	Ramsey, Amy J. Milenkovic, Marija Oliveira, Ana F. Yasmin, Escobedo-lozoya Seshadri, Saurav Ali, Salahpour Sawa, Akira Yasuda, Ryohei Caron, Marc G.
Abstract	NMDA receptors are key regulators of synaptic plasticity, and their hypofunction is thought to contribute to the pathophysiology of CNS disorders. Furthermore, NMDA receptors participate in the formation, maintenance, and elimination of synapses. The consequences of NMDA receptor hypofunction on synapse biology were explored in a genetic mouse model, in which the levels of NMDA receptors are reduced to 10% of normal levels (i.e., NR1-knockdown mice). In these mice, synapse number is reduced in an age-dependent manner; reductions are observed at the postpubertal age of 6 wk, but normal at 2 wk of age. Efforts to uncover the biochemical underpinnings of this phenomenon reveal synapse-specific reductions in 14–3-3ε protein and in Disrupted in Schizophrenia-1 (DISC1), two schizophrenia susceptibility factors that have been implicated in the regulation of spine density. Subchronic administration of MK-801, an NMDA receptor antagonist, produces similar synaptic reductions in both spine density and DISC1, indicating that synaptic levels of DISC1 are regulated by NMDA receptor function. The synaptic reduction of DISC1 and 14–3-3ε is developmentally correlated with the age-dependent decrease in striatal spine density.
Related Links	http://dx.doi.org/10.1073/pnas.1012621108
Ending Page	5800
Page Count	6
Starting Page	5795
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	108
Language	English
Publisher	National Academy of Sciences
Publisher Date	2011-04-05
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner.

Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner

Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

Cannabinoid Receptor 2 Alters Social Memory and Microglial Activity in an Age-Dependent Manner

Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner

PRENATAL MALNUTRITION ALTERS DIAZEPAM-MEDIATED SUPPRESSION OF ULTRASONIC VOCALIZATIONS IN AN AGE DEPENDENT MANNER

The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: Evidence for multiquantal release

Cocaine-Induced Synaptic Redistribution of NMDARs in Striatal Neurons Alters NMDAR-Dependent Signal Transduction

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner

Similar Documents

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner.

Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner

Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase

Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression

Cannabinoid Receptor 2 Alters Social Memory and Microglial Activity in an Age-Dependent Manner

Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner

PRENATAL MALNUTRITION ALTERS DIAZEPAM-MEDIATED SUPPRESSION OF ULTRASONIC VOCALIZATIONS IN AN AGE DEPENDENT MANNER

The high variance of AMPA receptor- and NMDA receptor-mediated responses at single hippocampal synapses: Evidence for multiquantal release

Cocaine-Induced Synaptic Redistribution of NMDARs in Striatal Neurons Alters NMDAR-Dependent Signal Transduction

Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner