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  1. Blood cells, molecules & diseases
  2. Year: 2011, Volume: 46
  3. Year: 2011, Volume: 46, Issue: 4
  4. Ex vivo Rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice*
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Year: 2015, Volume: 55
Year: 2015, Volume: 54
Year: 2014, Volume: 53
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Year: 2011, Volume: 47
Year: 2011, Volume: 46
Year: 2011, Volume: 46, Issue: 4
Molecular Basis of Two Novel Mutations Found in Type I Methemoglobinemia
Ex vivo Rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice*
Year: 2011, Volume: 46, Issue: 3
Year: 2011, Volume: 46, Issue: 1
Year: 2010, Volume: 45
Year: 2010, Volume: 44
Year: 2009, Volume: 43
Year: 2009, Volume: 42
Year: 2008, Volume: 41
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Ex vivo Rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice*

Content Provider PubMed Central
Author Rohrabaugh, Sara L. Campbell, Timothy B. Giao, Hangoc Broxmeyer, Hal E.
Abstract Since cord blood (CB) has become a commonly used source of transplantable hematopoietic stem (HSC) and hematopoietic progenitor cells (HPC), there has been a need to overcome the limited HSC and HPC numbers available to transplant from a single CB, especially for adult recipients. Our laboratory previously demonstrated that Rheb2 overexpression significantly impaired the repopulating ability of HSC. Since overexpression of Rheb2 leads to increased signaling through mTOR, we examined the effect of the mTOR inhibitor rapamycin ex vivo on cytokine expanded CD34+ CB cells for the engraftment of these cells in non-obese diabetic, severe combined immunodeficient, IL-2 receptor γ chain null (NSG) mice. We observed significant enhancement in engraftment of the CB treated ex vivo with cytokines in the presence of rapamycin prior to transplant, effects seen in primary as well as secondary transplants. These pre-clinical results suggest a positive role for rapamycin during ex vivo culture of CB SCID repopulating cells/HSC.
Related Links http://dx.doi.org/10.1016/j.bcmd.2011.02.006
Ending Page 320
Page Count 3
Starting Page 318
File Format PDF
ISSN 10799796
e-ISSN 10960961
Journal Blood cells, molecules & diseases
Issue Number 4
Volume Number 46
Language English
Publisher Date 2011-04-01
Access Restriction Open
Subject Keyword Molecular Medicine Cell Biology Molecular Biology Hematology Research in Higher Education
Content Type Text
Resource Type Article
Subject Cell Biology Hematology Molecular Biology Molecular Medicine
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