NDLI: RXRα ablation in epidermal keratinocytes enhances UV radiation induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes

Content Provider	PubMed Central
Author	Wang, Zhixing Coleman, Daniel J. Bajaj, Gaurav Liang, Xiaobo Gitali, Ganguli-indra Indra, Arup Kumar
Abstract	We show here that keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) regulates mouse keratinocyte and melanocyte homeostasis following acute ultraviolet radiation (UVR). Keratinocytic RXRα has a protective role on UVR-induced keratinocyte and melanocyte proliferation/differentiation, oxidative stress mediated DNA damage and cellular apoptosis. We discovered that keratinocytic RXRα in a cell autonomous manner regulate mitogenic growth responses in skin epidermis via secretion of hbEGF, GMCSF, IL1-α and COX2, and activation of MAPK pathways. We identified altered expression of several keratinocyte-derived mitogenic paracrine growth factors such as ET-1, HGF, α–MSH, SCF and FGF2 in skin of mice lacking RXRα in epidermal keratinocytes (RXRαep−/− mice), which in a non-cell autonomous manner modulated melanocyte proliferation and activation after UVR. RXRαep−/− mouse represents a unique animal model where UVR induces melanocyte proliferation/activation in both epidermis and dermis. Considered together, our results suggest that RXR antagonists, together with inhibitors of cell proliferation can be effective to prevent solar UV radiation induced photo-carcinogenesis.
Related Links	http://dx.doi.org/10.1038/jid.2010.290
Ending Page	187
Page Count	11
Starting Page	177
File Format	PDF
ISSN	0022202X
e-ISSN	15231747
Journal	The Journal of investigative dermatology
Issue Number	1
Volume Number	131
Language	English
Publisher Date	2011-01-01
Access Restriction	Open
Subject Keyword	Cell Biology Biochemistry Molecular Biology Dermatology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Biochemistry Molecular Biology Dermatology

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